Abstract
X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by networks of hydrogen bonds to form four edge-linked pentagons per asymmetric unit. These pentagons have a general role in maximizing hydrogen bonding at 3.4-Å intervals. The conformation of the deoxyribose sugar ring at the 3′ end of one strand can depend on its local aqueous environment.
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Neidle, S., Berman, H. & Shieh, H. Highly structured water network in crystals of a deoxydinucleoside–drug complex. Nature 288, 129–133 (1980). https://doi.org/10.1038/288129a0
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DOI: https://doi.org/10.1038/288129a0
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