Abstract
THERE is no doubt that long-chain aliphatic acids are intimately connected with the metabolism of Mycobacterium tuberculosis. Anderson1 has isolated a number of such acids, including a long-chain hydroxy-acid, from the fatty envelope of this organism. Adams2 has shown that acids of the type RR'CH.COOH (containing 16–18 carbon atoms) are, to a certain extent, bactericidal towards M. tuberculosis, and Robinson3 has synthesized acids of the type R"R"'C(CH3).CH2.COOH (containing 16–18 carbon atoms) which also showed bactericidal activity against this same organism.
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References
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ROBERTS, J. Aliphatic Acids, Fungi and Mycobacterium tuberculosis. Nature 155, 697–698 (1945). https://doi.org/10.1038/155697a0
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DOI: https://doi.org/10.1038/155697a0
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