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Isolation of a Crystalline Disaccharide, Hyalobiuronic Acid, from Hyaluronic Acid

Nature volume 168, pages 996–997 (1951)Cite this article

Abstract

THE structure of hyaluronic acid, an important constituent of the ‘ground substance’, has been the subject of intensive study in recent years. Applications of conventional methylation and periodate consumption methods to the intact polysaccharide1,2 have indicated that such methods will not yield substantial evidence of structure. The isolation and clarification of structure of crystalline oligosaccharides derived from hyaluronic acid is the most rigorous method of studying the structural details of this physiologically important substance. Such well-defined compounds are also required as models for establishing the specificity of the enzyme systems acting on hyaluronic acid.

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Authors and Affiliations

  1. Department of Medicine, Columbia University College of Physicians and Surgeons,

    MAURICE M. RAPPORT, BERNARD WEISSMANN, ALFRED LINKER & KARL MEYER

  2. the Edward Daniels Faulkner Arthritis Clinic, Presbyterian Hospital, New York, 32, N.Y.

    MAURICE M. RAPPORT, BERNARD WEISSMANN, ALFRED LINKER & KARL MEYER

Authors
  1. MAURICE M. RAPPORT
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  2. BERNARD WEISSMANN
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  3. ALFRED LINKER
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  4. KARL MEYER
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RAPPORT, M., WEISSMANN, B., LINKER, A. et al. Isolation of a Crystalline Disaccharide, Hyalobiuronic Acid, from Hyaluronic Acid. Nature 168, 996–997 (1951). https://doi.org/10.1038/168996b0

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