Abstract
IN the course of an investigation of the mechanism of enzymatic oxidation of serotonin (5-hydroxytryptamine) by human serum1, we found that apparently identical chromatographic reaction products2 resulted when this oxidation was catalysed non-enzymatically by cupric ion. We became curious as to what extent transitional metals other than copper catalysed this reaction, and expanded our investigation to include a study of the relative catalytic effectiveness of 18 transitional elements in the oxidations of related compounds of biological interest.
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References
Martin, G., Benditt, E. P., and Eriksen, N., Fed. Proc., 17, 447 (1958).
Eriksen, N., Martin, G. M., and Benditt, E. P., J. Biol. Chem. (in the press).
Jackson, D. E., J. Pharmacol. and Exp. Therap., 3, 477 (1912).
Martin, G. M., Benditt, E. P., and Eriksen, N., Fed. Proc., 18, 492 (1959).
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MARTIN, G., BENDITT, E. & ERIKSEN, N. Vanadium Catalysis of the Oxidation of Catechol Amines, Dihydroxyphenylalanine and 5-Hydroxyindoles. Nature 186, 884–885 (1960). https://doi.org/10.1038/186884a0
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DOI: https://doi.org/10.1038/186884a0
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