Abstract
THE lability of human antihæmophilic factor in both plasma and concentrates is a major hazard during purification, even when the reaction of solutions is maintained within the rather restricted optimum range of stability, which we find to be pH 7.1–7.2, and when preparative procedures are conducted at temperatures close to 0°.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cohn, E. J., Strong, L. E., Hughes, W. L., Mulford, D. J., Ashworth, J. N., Melin, M., and Taylor, H. L., J. Amer. Chem. Soc., 68, 549 (1946).
Kekwick, R. A., Mackay, M. E., Nance, M. H., and Record, B. R., Biochem. J., 60, 671 (1955).
Kekwick, R. A., and Wolf, P., Lancet, i, 647 (1957).
Wagner, R. H., Brinkhous, K. M., and Penick, G. D., in Hæmophilia and other Hæmorrhagic States, edit. by Brinkhous, K. M. (Univ. N. Carolina Press, Chapel Hill, N. C.).
Alkjaersig, N., Fletcher, A. P., and Sherry, S., J. Biol. Chem., 234, 832 (1959).
Pool, J. G., and Robinson, J., Brit. J. Hæmat., 5, 17 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KEKWICK, R., WALTON, P. Conditions influencing the Stability of Human Antihæmophilic Factor. Nature 194, 878–879 (1962). https://doi.org/10.1038/194878a0
Issue Date:
DOI: https://doi.org/10.1038/194878a0
This article is cited by
-
Reindarstellung von faktor V und VIII
Blut Zeitschrift für die Gesamte Blutforschung (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.