Abstract
THE hallucinogenic drug, lysergic acid diethylamide (LSD-25), produces in minute doses marked aberrations in mental functions. The psychic symptoms of LSD-25 intoxication resemble aspects peculiar to schizophrenia1,2. As a result, the drug has been utilized as an effective tool to explore the induction of reversible psychoses in non-psychotic subjects. It has been assumed that the similarities produced by LSD-25 could yield information pertinent to the mechanisms and pathophysiology involved in schizophrenia2,3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Forrer, G. R., and Goldner, R. D., Arch. Neurol. Psychiat., 65, 581 (1951).
Lingjaerde, P., and Skaug, O. E., J. Nerv. Mental Dis., 124, 578 (1956).
Sackler, A. M., Sackler, R. R., Marti-Ibanez, F., and Sackler, M. D., J. Clin. and Exp. Psychopath., 15, 382 (1954).
Härkönen, P., and Konttinen, Y., Acta Pharm. Toxicol., 14, 104 (1958).
Feld, M., Goodman, J. R., and Guido, J. A., J. Nerv. Mental Dis., 126, 176 (1958).
Gordon, A. S., Ann. N.Y. Acad. Sci., 59, 907 (1955).
Rothlin, C., Cerletti, A., Konzett, H., Schalch, W. R., and Taeschler, M., Experientia, 12, 154 (1956).
Lovell, R. R. H., Osborne, J. A., Goodman, H. C., and Hudson, B., Lancet, i, 970 (1953).
Milkovic, S., and Supek, Z., Arch. Exp. Path. Pharmakol., 228, 146 (1956).
Belsanti, E., Acta Neurologica, 7, 340 (1952).
Todd, J. E., and Sanford, A. H., Clinical Diagnosis, tenth ed. (W. B. Saunders, Philadelphia, 1944).
Hennenman, P. H., Wexler, H., and Westerhaver, M. M., J. Lab. Clin. Med., 34, 1017 (1949).
Sackler, M. D., Sackler, R. R., Sackler, A. M., and van Ophuijsen, J. H. W., Amer. J. Psychiat., 108, 669 (1952).
Altschule, M. D., New Eng. J. Med., 257, 919 (1957).
Sackler, M. D., Sackler, R. R., Sackler, A. M., Co Tui, and van Ophuijsen, J. H. W., Acta Psychiat. Neurol. Scand., 26, 415 (1951).
Sackler, M. D., Sackler, R. R., Sackler, A. M., La Burt, H. A., van Ophuijsen, J. H. W., and Co Tui, Psychiat. Quart., 25, 213 (1951).
Sackler, A. M., Sackler, R. R., Marti-Ibanez, F., and Sackler, M. D., J. Clin. and Exp. Psychopath., 15, 382 (1954).
Sackler, M. D., Sackler, R. R., Marti-Ibanez, F., and Sackler, A. M., Quart. Rev. Psychiat. and Neurol., 17, 297 (1956).
Sackler, A. M., Weltman, A. S., and Jurtshuk, jun., P., Aerospace Medicine, 31, 749 (1960).
Weltman, A. S., Sackler, A. M., and Gennis, J., J. App. Physiol., 16, 587 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SACKLER, A., WELTMAN, A. & SPARBER, S. Effects of Lysergic Acid Diethylamide on the Total Leukocytes and Eosinophils of the Female Rat. Nature 199, 1194–1195 (1963). https://doi.org/10.1038/1991194a0
Issue Date:
DOI: https://doi.org/10.1038/1991194a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.