Abstract
WE have found recently1 that addition of phospho-glyeeric acid to frog's muscle pulp, poisoned with iodoacetic acid, stops the formation of ammonia which is released by this poison ; and we have explained this effect of phosphoglycerate, and a similar action of pyruvic salts in fluoride poisoned muscle, by the hypothesis that the resynthesis of adenosinetriphosphoric acid—which cannot be de-aminated directly in muscle—is kept going, in absence of glycogenolysis, by the transport of phosphate groups to adenylic acid from phosphoglyceric acid, or from a related phosphate carrier. This transport we have supposed to be indirect ; from the intermediary product of glycogenolysis, the phosphate group being transported to creatine, with formation of phosphocreatine, from which it is transported, in Lohmann's reaction, to adenylic acid as phosphate acceptor. The supposed intermediary reaction of the intermediary phosphorus compound with creatine we have written in our scheme of glycogenolysis2 as reaction (3).
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References
Biochem. Z., 64, 272; 1934.
NATURE, 134, 627, Oct. 20, 1934.
Biochem. Z., 60, 273 ; 1934.
Not published, read in Basel, May 1933.
NATURE, 132, 337 (v.p. 340), Sept. 2, 1933.
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PARNAS, J., OSTERN, P. & MANN, T. Linkage of Chemical Changes in Muscle. Nature 134, 1007 (1934). https://doi.org/10.1038/1341007a0
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DOI: https://doi.org/10.1038/1341007a0
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