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Taming transplantation with T cells

Nature Medicine volume 9, pages 1117–1118 (2003)Cite this article

Transplantation of bone marrow between allogeneic donors and recipients poses the risk of developing graft-versus-host disease, mediated by T cells from the graft. Exploitation of naturally occurring regulatory T cells in the graft minimizes this risk while still allowing another crucial function of graft T cells—the eradication of host tumor cells. (pages 1144–1150)

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Figure 1: Control of GVHD and GVT activity by regulatory T (TR) cells in allogeneic bone marrow transplantation.

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  1. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, 606-8507, Kyoto, Japan

    Shimon Sakaguchi

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  1. Shimon Sakaguchi
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Sakaguchi, S. Taming transplantation with T cells. Nat Med 9, 1117–1118 (2003). https://doi.org/10.1038/nm0903-1117

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