CREB phosphorylation is required for transcriptional activation, but how dephosphorylation couples with decreased transcription activity was less obvious. New findings indicate that CREB can recruit histone deacetylase HDAC1 and protein phosphatase 1 in a concerted action, thus leading to attenuated transcription.
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Sassone-Corsi, P. The decline of induced transcription: a case of enzymatic symbiosis. Nat Struct Mol Biol 10, 151–152 (2003). https://doi.org/10.1038/nsb0303-151
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DOI: https://doi.org/10.1038/nsb0303-151
