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Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation

Nature Structural & Molecular Biology volume 14, pages 572–573 (2007)Cite this article

MicroRNAs are small, noncoding RNAs that regulate gene expression in eukaryotes. The multipurpose protein hnRNP A1, a well-known factor in the regulation of precursor messenger RNA splicing, has now been implicated in the biogenesis of the microRNA miR-18a, shedding further light on the emerging topic of post-transcriptional regulation of microRNA expression.

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Figure 1: Proposed functions of hnRNP A1 in post-transcriptional regulation of miRNA expression.

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Acknowledgements

We thank K. Heindl and S. Weitzer for critically reading the manuscript.

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Authors and Affiliations

  1. Anne Færch Nielsen is in the Department of Molecular Biology, University of Aarhus, CF Møllers Allé 1130, 8000 Aarhus C, Denmark,

    Anne Færch Nielsen

  2. Philipp J. F. Leuschner and Javier Martinez are at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr.-Bohr-Gasse 3, 1030, Vienna, Austria. javier.martinez@imba.oeaw.ac.at,

    Philipp J F Leuschner & Javier Martinez

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Nielsen, A., Leuschner, P. & Martinez, J. Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation. Nat Struct Mol Biol 14, 572–573 (2007). https://doi.org/10.1038/nsmb0707-572

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