Biochimica et Biophysica Acta (BBA) - General Subjects
Increased transglutaminase activity during skin wound healing in rats
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Cited by (55)
Enhanced transglutaminase 2 expression in response to stress-related catecholamines in macrophages
2014, ImmunobiologyCitation Excerpt :TG2 appears to promote net formation of ECM molecules such as fibronection and collagen by irreversible crosslinking of these molecules in tissue repair. TG2 expression and activity were increased following cutaneous wounding in animal models (Bowness et al. 1988; Upchurch et al. 1991; Raghunath et al. 1996). In addition, infiltrating macrophages in injured tissue express TG2 (Haroon et al. 1999).
Hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen - The role of tissue transglutaminase
2005, Journal of Investigative DermatologyCitation Excerpt :The stabilization of newly formed ECM is thought to be largely accomplished through the actions of tissue transglutaminase (or transglutaminase II) (Ricard-Blum et al, 1996; Grenard et al, 2001). The activity of this enzyme is markedly increased during wound healing, substantially effecting both the breaking strength of wounds and the solubility of ECM proteins (Bowness et al, 1987b,1988; Dolynchuk et al, 1994; Haroon et al, 1999). Tissue transglutaminase cross-links proteins through the formation of isopeptide bonds between reactive γ-glutaminyl groups in certain specific proteins and the ε-amino group of lysine in other proteins.
Atorvastatin induces tissue transglutaminase in human endothelial cells
2004, Biochemical and Biophysical Research CommunicationsImportance of tissue transglutaminase in repair of extracellular matrices and cell death of dermal fibroblasts after exposure to a solarium ultraviolet a source
2003, Journal of Investigative DermatologyCitation Excerpt :From a more physiologic context we have also observed this increase in matrix associated tTgase activity without increase in enzyme expression in the tubulo-interstitium of rat kidney during renal scarring for hyperglycemia (Skill et al, 2001). A comparable observation was also demonstrated byBowness et al (1988) following the mechanical wounding of rat skin. Like factor XIIIa, tTgase may therefore have a defined physiologic function in the wound healing process through the stabilization of extracellular matrix proteins such as fibronectin and other extracellular matrix proteins known to act as substrates for the enzyme (Aeschlimann and Thomazy, 2000) following tissue damage.
Transglutaminase-mediated gelatin matrices incorporating cell adhesion factors as a biomaterial for tissue engineering
2003, Journal of Bioscience and Bioengineering