Biochimica et Biophysica Acta (BBA) - General Subjects
Specific inhibition of candicidin biosynthesis by the lipogenic inhibitor cerulenin
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A pipeline for the genetic improvement of a biological control agent enhances its potential for controlling soil-borne plant pathogens
2021, Biological ControlCitation Excerpt :The molecule inhibits the synthesis of melanin, a polymer with the utmost relevance to the processes of disease development in plants, either contributing to the penetration of the pathogen or protecting the pathogen from stresses. Ohno et al. (1975) and Martin and McDaniel (1975) showed that melanin production in fungi is linked to polyketide pathway and cerulenin has the property to inhibit the polyketide synthesis by inhibiting the malonyl-ACP:acyl-ACP condensation reaction and fatty acid synthesis. As an example, the molecule is the main component of sclerotium structure. (
chapter 10 Enzymology of the Polyenes Pimaricin and Candicidin Biosynthesis
2009, Methods in EnzymologyCitation Excerpt :Twenty-one ORFs extending for 137.2 kb of contiguous DNA have been identified (Table 10.2). Initial evidence based on the incorporation of labeled PABA established that PABA is the direct precursor of the para-aminobenzoyl-CoA starter unit of the polyketide chain (Martín and Liras, 1976; Martín and McDaniel, 1975). The PABA synthase of S. griseus, an enzyme involved in the biosynthesis of para-aminobenzoic acid from chorismic acid, was purified and characterized (Gil et al., 1980, 1985).
The biosynthesis of differentiation-inducing factor, a chlorinated signal molecule regulating Dictyostelium development
1998, Journal of Biological ChemistryInhibition of melanin biosynthesis by cerulenin in appressoria ofColletotrichum lagenarium
1986, Experimental MycologyEnzymes of secondary metabolism in microorganisms
1986, Trends in Biochemical Sciences
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Present address: Departmento de Microbiologia, C.S.I.C., Facultad de Ciencias, Universidad de Salamanca, Salamanca, Spain.