Elsevier

Biochimie

Volume 76, Issues 10–11, 1994, Pages 1071-1074
Biochimie

Characterization of mutant alleles of the cell division protein FtsA, a regulator and structural component of the Escherichia coli septator

https://doi.org/10.1016/0300-9084(94)90032-9Get rights and content

Abstract

Two alleles of ftsA, a gene that encodes an essential cell division protein in Escherichia coli, have been mapped at the nucleotide level. The mutations are located inside domains that are conserved in an ATP-binding protein family. The ftsA2 mutation lies in the adenine-binding domain, and the ftsA3 in the ribose-binding domain. The defect in ampicillin binding to PBP3 described for allele ftsA3 is allele-specific. This supports the hypothesis of the existence of different domains in FtsA having different functions.

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  • ∗∗

    These authors contributed equally to this publication.

    1

    Present address: Instituto Cajal, Av Doctor Arce 37, 28002 Madrid, Spain.

    2

    Present address: Departamento de Microbiología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

    3

    Present address: Department of Biological Sciences, Napier University, Edinburgh EH10 5DT, Scotland, UK.

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