Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Short sequence-paperNucleotide sequence of a complementary DNA for human ST2
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Cited by (55)
Role of the IL-33/ST2L axis in colorectal cancer progression
2019, Cellular ImmunologyCitation Excerpt :Mature IL-33 protein lacking the N-terminal domain acts as an IL-1-like cytokine through its C-terminal IL-1-like cytokine domain. ST2, an IL-33 receptor encoded by the IL1RL1 gene, is a member of the IL-1 receptor family that was originally identified as a responsive gene in serum- or oncogene-stimulated mouse fibroblasts [34,35]. At least four ST2 isoforms are produced from the IL1RL1 gene via alternative splicing: ST2L, sST2, ST2V and ST2LV.
ST2 and the ST2/IL-33 signalling pathway–biochemistry and pathophysiology in animal models and humans
2019, Clinica Chimica ActaCitation Excerpt :More details are reported in Section 2.1.1 in this review. The soluble form of ST2 is identical to the extracellular region of the long ST2 isoform except for five additional amino acids, which are present at the C-terminus of the molecule [33]. Soluble ST2 is composed of 328 amino acids (UniProt, https://www.uniprot.org/uniprot/Q01638, last access 04/16/2019).
Serum ST2 as a potential prognostic biomarker for traumatic brain injury
2018, Clinica Chimica ActaCitation Excerpt :Undoubtedly, their early predictions are beneficial to clinical treatment for TBI patients. ST2 is identified as the receptor of interleukin-33 and belongs to the interleukin-1 receptor family [41–48]. ST2 combined with interleukin-33 activates inflammatory reaction and is subsequently implicated in pathophysiological process underlying some inflammatory diseases, such as trauma, acute myocardial infarction and acute pancreatitis [49–52].
Reconstitution of ST2 (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP) shared with IL-1
2016, CytokineCitation Excerpt :ST2 (also known as IL-1RL1, DER4, Fit-1, or T1) is known as an orphan receptor of the interleukin (IL)-1 receptor family [1–5] and a selective marker of T helper (Th) 2 cells in human and mouse cells [6].
The IL-33/ST2 axis: Role in health and disease
2015, Cytokine and Growth Factor Reviews