Preliminary communication
Solid (gel) phase synthesis of fully-protected acylpeptide hydrazides with hydrazine-labile sidechains

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Abstract

A simple, efficient strategy for the preparation of fully-protected acylpeptide hydrazides with hydrazine-labile sidechains is described. The method involves controlled hydrazinolytic cleavage of target peptides from assemblies elaborated by solid (gel) phase synthesis on phenolic peptide resins.

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