Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
BBA ReportTetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity
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Cited by (46)
Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages
2013, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The remodeling pathway for PAF synthesis is thought to be responsible for the formation of PAF from lyso-PAF in response to inflammatory and immune stimuli, while the de novo pathway for PAF synthesis is believed to be more constitutive. Despite structural similarities to lyso-PAF, previous studies showed that none of the 1-O-alkyllipids in the de novo pathway for PAF synthesis was a good substrate for BH4-dependent enzyme activity [7,22]. Other ether lipids, such as plasmalogens (suggested to be involved in the myelination process [23]), monoalkylglycerol (which induces PKC inhibition in cell cultures of MDCK cells [24] and affects adipogenesis [25]), and alkyl-LPA (which may play a role in the nervous system [26], skeletal muscle [27] and platelets [28]), can be directly or indirectly affected by AGMO but await further investigation.
Orphan enzymes in ether lipid metabolism
2013, BiochimieCitation Excerpt :Alkylglycerol monooxygenase (E.C. 1.14.16.5) (P) is a tetrahydrobiopterin-dependent enzyme which cleaves the ether bond of 1-O-alkyl-sn-glycerols (19, 20, 25) via a hydroxylation and subsequent rearrangement of the resulting hemiacetal into a fatty aldehyde (15) and a glycerol derivative (21). It accepts alkylglycerols which are unsubstituted at sn-3 or which carry a wide range of common phospholipid substitutions at sn-3, except the phosphate group alone as in (4), which is no substrate of the enzyme [43]. The enzyme requires, however, a free hydroxy group at sn-2 and cannot cleave lipids which carry a vinyl ether bond.
Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase"
2005, Journal of Biological ChemistryPlatelet-activating factor and its analogs: metabolic pathways and related intracellular processes
1995, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid MetabolismLysophospholipase D
1991, Methods in EnzymologyDependence of an alkyl glycol-ether monooxygenase activity upon tetrahydropterins
1990, Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular