Biochemical and Biophysical Research Communications
Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm
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2018, Experimental GerontologyCitation Excerpt :In addition, the culprit lesions of patients with shorter LTL had an increaed necrotic core compoenent (59 mm3 vs. 47 mm3, P = 0.022) and exhibited more often a TCFA phenotype (OR: 1.75, P = 0.002). Mitochondrial DNA (mtDNA) mutations are seen more often in elderly patients (Hayakawa et al., 1992; Hayakawa et al., 1991) and appear to lead to impaired mitochondrial function which increases local oxidative stress and promotes vulnerable plaque formation (Fujimoto et al., 2010; Mercer et al., 2010; Tatarkova et al., 2011). In a recent histology study Yu et al. demonstrated that mtDNA damage was two-fold increased in carotid endarterectomy plaques compared to normal aortas (Yu et al., 2013).
Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC–MS/MS
2017, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :Additionally, urinary creatinine concentration is required to normalize urine volume for urinary 8-OHdG calibration [16]. A variety of biochemical and chemical assays have been developed for 8-OHdG analysis, including enzyme-linked immunosorbent assay (ELISA) [24], 32P post-labeling [25], capillary electrophoresis-ultraviolet detection (CE-UV) [26], high-performance liquid chromatography-electrochemical detection (HPLC-ECD) [27], gas chromatography–mass spectrometry (GC–MS) [28], liquid chromatography-tandem mass spectrometry (HPLC–MS/MS) [29–31] and liquid chromatography-single mass spectrometry (HPLC–MS) [32,33]. HPLC-ECD is frequently utilized, however, complicated HPLC system with column-switching [34] or SPE [35] is necessary to eliminate possible interference from various sample matrix.
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases
2017, Ageing Research ReviewsCitation Excerpt :The most common oxidative lesions in mtDNA are the G:C to T:A transversion mutations caused by adenine pairing with the guanine adduct 7,8-dihydro-8-oxo-deoxyguanosine (8-oxo-dG) (Wang et al., 1998). Correlative evidence between increased levels of 8-oxo-dG and age-related deletions in mtDNA from humans (Capel et al., 2005; Hayakawa et al., 1992; Hayakawa et al., 1991), mice (Vermulst et al., 2007), rats (Sawada and Carlson, 1987) and houseflies (Sohal and Sohal, 1991) has been reported. Conversely, G:C to T:A transversions are only a small fraction of the mutations found in aged Drosophila (Itsara et al., 2014) or humans (Kennedy et al., 2013; Zheng et al., 2006).
Oxidants and Mitochondrial Decay in Aging
2012, Natural Antioxidants in Human Health and DiseaseFunctional interplay between mitochondrial and proteasome activity in skin aging
2011, Journal of Investigative DermatologyCitation Excerpt :Thus, excess production of ROS increases oxidative damage to mtDNA (Hayakawa et al., 1992). Accordingly, the accumulation of point mutations (Hayakawa et al., 1991) and large-scale deletions (Cortopassi and Arnheim, 1990) of mtDNA has been observed in samples from aged donors (for recent review, see Wiesner et al., 2006; Pang et al., 2008). Mitochondrial respiratory activity was reported to decrease with age in several human tissues, such as the liver (Yen et al., 1989) and skeletal muscle (Trounce et al., 1989; Conley et al., 2000).
Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury
2010, Mechanisms of Ageing and Development