Highly stereoselective synthesis of α-hydroxy β-amino acids through β-lactams: application to the synthesis of the taxol and bestatin side chains and related systems.

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Abstract

Formation of α-hydroxy β-lactams, followed chemical elaboration at C4 and further βlactam cleavage afforded functionalised α-hydroxy β-amino acids or their derivatives in a highly stereoselective manner.

Formation of α-hydroxy β-lactams, followed by chemical elaboration at C4 and further β-lactam cleavage afforded α-hydroxy β-amino acids or their derivatives in a highly stereoselective manner.

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