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Cited by (35)
Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with amino acid ligands in various coordination modes
2013, Inorganica Chimica ActaCitation Excerpt :Analogous couplings were observed in some other amino acid complexes of platinum [30]. Anionic chelating amino acid ligands produce invariably a downfield shift of the proton resonances, relative to their corresponding amino acid anions [31,32]. Furthermore, the resonances of the α protons were found to be more shielded in complexes with monodentately coordinated (κO) amino acid ligands than with bidentately coordinated (κO,κN; κ2O,O′) amino acid ligands (cf. complexes 7/9 and 11/12).
Water-soluble platinum(II) complexes of diamine chelating ligands bearing amino-acid type substituents: The effect of the linked amino acid and the diamine chelate ring size on antitumor activity, and interactions with 5′-GMP and DNA
2004, Journal of Inorganic BiochemistryCitation Excerpt :Since 1975 different Pt(II) complexes bearing amino acids or peptides have been described [19–23], attracting the attention of scientists until now [24–29]. Different substitutions on the amine moiety of cisplatin have been described to modify the kinetics of the DNA binding, due to either the presence of charges, hydrogen bond formation, or steric effects [12,30–36]. We are therefore interested in how different substituents on the amine moiety of cisplatin derivatives can modulate the drug availability.
Three new platinum(II)-dipeptide complexes
1999, Journal of Inorganic Biochemistry