Elsevier

FEBS Letters

Volume 312, Issues 2–3, 9 November 1992, Pages 229-235
FEBS Letters

Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain

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Abstract

The complete amino acid sequence of a novel ryanodine receptor/calcium release channel from rabbit brain has been deduced by cloning and sequence analysis of the EDNA. This protein is composed of 4872 amino acids and shares characteristic structural features with the skeletal muscle and cardiac ryanodine receptors. RNA blot hybridization analysis shows that the brain ryanodine receptor is abundantly expressed in corpus striatum, thalamus and hippocampus, whereas the cardiac ryanodine receptor is more uniformly expressed in the brain. The brain ryanodine receptor gene is transcribed also in smooth muscle.

Keywords

Ryanodine receptor
Calcium release channel
cDNA cloning
RNA blot hybridization
Smooth muscle
Rabbit brain

Abbreviations

ER
endoplasmic reticulum
IP3
inositol 1,4,5-tris-phosphate
SR
sarcoplasmic reticulum
T-tubule
transverse tubule

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1

Present address: International Institute for Advanced Studies, Shimadzu Corporation N-80-3F, 1 Nishinokyo-Kuwabara-cho, Nakagyo-ku, Kyoto 604, Japan.