A dicarba analog of β-atrial natriuretic peptide (β-ANP) inhibits guanosine 3′,5′-cyclic monophosphate production induced by α-ANP in cultured rat vascular smooth muscle cells
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Keywords
Atrial natriuretic peptide analog
Atrial natriuretic peptide receptor antagonist
Receptor binding
cyclic GMP production
Vasorelaxation
(Cultured vascular smooth muscle cell)
Abbreviations
Acm, acetamidomethyl
ANP, atrial natriuretic peptide
Boc, tert-butyloxycarbonyl
Bzl, benzyl
cGMP, guanosine 3′,5′-cyclic monophosphate
Dcb, 2,6-dichlorobenzyl
DCC, dicyclohexylcarbodiimide
EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
HOBt, 1-hydroxybenzotriazole
HOSu, N-hydroxysuccinimide
HPLC, high-performance liquid chromatography
PGF2α, prostaglandin F2α
TFA, trifluoroacetic acid
VSMC, cultured vascular smooth muscle cells
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Copyright © 1989 Published by Elsevier B.V.