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Protein kinases in protists

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Summary

The vast preponderance of our understanding of protein kinases comes from studies of mammalian or of other higher eukaryotic systems. A survey of the Wilson reference databank yielded 3,807 citations for protein kinases; only nine of these were reports of protein kinases in protists. It is apparent, nonetheless, that this understudied group offers unique opportunities for resolving the mechanisms by which protein kinases mediate a variety of cellular processes. Moreover, generalities about cofactor requirements (e.g., Ca2+ alone activates many protist protein kinases), substrate specificity, and the nature of the enzymes themselves (monomeric versus dimeric cyclic-nucleotide dependent protein kinases) will certainly need to be modified.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Illinois at Chicago, 60607-7060, Chicago, IL, USA

    M. J. Fazio, J. A. Marrs & G. B. Bouck

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  1. M. J. Fazio
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  2. J. A. Marrs
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  3. G. B. Bouck
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Fazio, M.J., Marrs, J.A. & Bouck, G.B. Protein kinases in protists. Protoplasma 181, 283–290 (1994). https://doi.org/10.1007/BF01666402

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