Abstract
A single recessive gene, ter (teratoma), causes germ cell deficiency and a high incidence of congenital testicular teratomas in the 129/Sv-ter strain of the mouse. Linkage analyses between the ter gene and 36 marker genes of 19 chromosomes were performed with matings between the C57BL/6J-ter congenic strain and four inbred strains. Results showed that the ter gene was linked to D18Mit9, D18Mit14, and D18Mit17 on Chromosome (Chr) 18. Gene order estimated on the basis of recombination distance (in centimorgans) was [centromere-D18Mit14-5.1 (cM)-ter-0 (cM)-D18Mit17-23.8 (cM)-D18Mit9]. D18Mit17 is the microsatellite DNA of the Grl-1 (glucocorticoid receptor-1) locus. We conclude that the ter gene is closely linked to Grl-1 on Chr 18 and is a new mutation involving the developmental modification of primordial germ cells in mice.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bennett, D. (1956). Developmental analysis of a mutation with pleiotropic effects in the mouse. J. Morphol. 98, 199–234.
Chabot, B., Stephenson, D.A., Chapman, V.M., Besmer, P., Bernstein, A. (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335, 88–89.
Copeland, N.G., Gilbert, D.J., Cho, B.C., Donovan, P.J., Jenkins, N.A., Cosman, D., Anderson, D., Lyman, S.D., Williams, D.E. (1990). Mast cell growth factor maps near the Steel locus on mouse chromosome 10 and is deleted in a number of Steel alleles. Cell 63, 175–183.
Cornall, R.J., Aitman, T.J., Hearne, C.M., Todd, J.A. (1991). The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome. Genomics 10, 874–881.
Dietrich, W., Katz, H., Lincoln, S.E., Shin, H-S., Friedman, J., Dracopoli, N., Lander, E.S. (1992). A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131, 423–447.
Geissler, E.N., Ryan, M.A., Housman, D.E. (1988). The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55, 185–192.
Green, M.C. (1981). Gene mapping. In The Mouse in Biomedical Research I, H.L. Foster, J.D. Small, J.G. Fox, eds. (New York: Academic Press), pp. 105–117.
Hashimoto, K., Noguchi, M., Nakatsuji, N. (1992). Mouse offspring derived from fetal ovaries or reaggregates which were cultured and transplanted into adult females. Dev. Growth Differ. 34, 233–238.
Hearne, C.M., McAleer, M.A., Love, J.M., Aitman, T.J., Cornall, R.J., Ghosh, S., Knight, A.M., Prins, J-B., Todd, J.A. (1991). Additional microsatellite markers for mouse genome mapping. Mamm. Genome 1, 273–282.
Hillyard, A.L., Doolittle, D.P., Davisson, M.T., Roderick, T.H. (1993). Locus map of mouse. Mouse Genome 91, 15–39.
Huang, E., Nocka, K., Beier, D.R., Chu, T-Y., Buck, J., Lahm, H.-W., Wellner, D., Leder, P., Besmer, P. (1990). The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63, 225–233, 1990.
Matsui, Y., Zsebo, K., Hogan, B.L.M. (1992). Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell 70, 841–847.
McCoshen, J.A., McCallion, D.J. (1975). A study of the primordial germ cells during their migratory phase in steel mutant mice. Experientia 31, 589–590.
Mintz, B., Russell, E.S. (1957). Gene-induced embryological modifications of primordial germ cells in the mouse. J. Exp. Zool. 134, 207–237.
Noguchi, T., Noguchi, M. (1985). A recessive mutation ter causes germ cells deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter. J. Natl. Cancer Inst. 75, 385–392.
Noguchi, T., Stevens, L.C. (1982). Primordial germ cell proliferation in fetal testes in mouse strain with high and low incidences of congenital testicular teratomas. J. Natl. Cancer Inst. 69, 907–913.
Noguchi, M., Sato, M., Mori, N., Hayashi, M., Kusakabe, M. (1993). Cooperative roles of oocyte and follicle in ovarian parthenogenesis and teratocarcinogenesis in mice: evidence from chimeric mice. In Biology of the Germ Line—in Animals and Man, H. Mohri, M. Takahashi, C. Tachi, eds. (Tokyo: Japan Scientific Societies Press, Karger), pp. 271–284.
Nomura, T., Esaki, K., Tomita, T. (1984). ICLAS Manual for Genetic Monitoring Manual of Inbred Mice. (Tokyo: University of Tokyo Press).
Ogita, Z., Markert, C.L. (1979). A miniaturized system for electrophoresis on polyacrylamide gels. Anal. Biochem. 99, 233–241.
Pellas, T.C., Ramachandran, B., Duncan, M., Pan, S.S., Marone, M., Chada, K. (1991). Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 8787–8791.
Resnick, J.L., Bixler, L.S., Cheng, L., Donovan, P.J. (1992). Long-term proliferation of mouse primordial germ cells in culture. Nature 359, 550–551.
Sambrook, J., Fritsch, E.F., Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. (Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press).
Shiroishi, T., Sagai, T., Moriwaki, K. (1981). A simplified micromethod for cytotoxicity testing using a flat-type titration plate for the detection of H-2 antigens. Microbiol. Immunol. 25, 1327–1334.
Stevens, L.C. (1967). Origin of testicular teratomas from primordial germ cells in mice. J. Natl. Cancer Inst. 38, 549–552.
Stevens, L.C. (1973). A new inbred subline of mice (129/terSv) with a high incidence of spontaneous congenital testicular teratomas. J. Natl. Cancer Inst. 50, 235–242.
Stevens, L.C., Mackensen, J.A. (1961). Genetic and environmental influences on teratocarcinogenesis in mice. J. Natl. Cancer Inst. 27, 443–453.
Whitney III, J.B., Copeland, G.T., Skow, L.C., Russel, E.S. (1979). Resolution of products of the duplicated hemoglobin alpha-chain loci by isoelectric focusing. Proc. Natl. Acad. Sci. USA 76, 867–871.
Witte, O.N. (1990). Steel locus defines new multipotent growth factor. Cell 63, 5–6.
Zsebo, K.M., Williams, D.A., Geissler, E.N., Broudy, V.C., Martin, F.H., Atkins, H.L., Hsu, R.-Y., Birkett, N.C., Okino, K.H., Murdock, D.C., Jacobsen, F.W., Langley, K.E., Smith, K.A., Takeishi, T., Cattanack, B.M., Galli, S.J., Suggs, S.V. (1990). Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63, 213–224.
Author information
Authors and Affiliations
Additional information
Deceased
Rights and permissions
About this article
Cite this article
Sakurai, T., Katoh, H., Moriwaki, K. et al. The ter primordial germ cell deficiency mutation maps near Grl-1 on mouse Chromosome 18. Mammalian Genome 5, 333–336 (1994). https://doi.org/10.1007/BF00356550
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00356550