Abstract
When carbon-14-labeled HEOD (dieldrin) is injected into the American cockroach, German cockroach, and house fly, metabolism takes place forming radioactive metabolites which have been isolated and identified by thin-layer chromatographic methods. The major metabolite of dieldrin in the American cockroach iscis-aldrindiol. This is the first report ofcis-aldrindiol being formed as a dieldrin metabolite and possible mechanisms for its formation are given. Other dieldrin metabolites identified or characterized indicate that both hydrolytic and oxidative systems are important in the metabolism of dieldrin by the three insect species studied. Thein vitro metabolism of HEOD-14C by the fat body from the American cockroach also supports the above conclusion.
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Nelson, J.O., Matsumura, F. Dieldrin (HEOD) metabolism in cockroaches and house flies. Arch. Environ. Contam. Toxicol. 1, 224–244 (1973). https://doi.org/10.1007/BF01985746
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DOI: https://doi.org/10.1007/BF01985746