Summary
The information contained in the composition of different proteins of the same family is analyzed. It is found that within each family the gain in information per amino acid replacement is constant. This finding is interpreted to imply that evolutionary changes in proteins follow an “optimal” path in the sense that they maximize the number of potentially functional sequences that can be generated by T accepted point mutations from a given protein, subject to restrictions due to biological function.
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References
Ben-Shaul, A., Hofacker, G.L. (1976). Statistical and Dynamical Models of Population Inversion. In: Handbook of Chemical Lasers, R.W.F. Gross and J.F. Bott, eds., pp. 579–617. New York: Wiley
Berg, A. van den, Beintema, J.J. (1975). Nature253, 207–210
Berg, A. van den, Hende-Timmer, L. van den, Beintema, J.J. (1976). BBA453, 400–409
Berg, A. van den, Hende-Timmer, L. van den, Hofsteenge, J., Gaastra, W., Beintema, J.J. (1977). Eur. J. Biochem.75, 91–100
Bogardt, R.A., Dwulet, F.E., Lehman, L.D., Jones, B.N., Gurd, F.R.N. (1976). Biochemistry15, 2597–2602
Castillo, O., Lehmann, H. (1977). BBA492, 232–236
Chirpich, T.P. (1975). Science188, 1022–1023
Dayhoff, M.O., Dayhoff, R.E., Hunt, L.T. (1976). Compositions of Proteins. In: Atlas of Protein Sequence and Structure, M.O. Dayhoff, ed., Vol. 5, Suppl. 2, p. 301. Silver Spring, Maryland: National Biomedical Research Society
Dayhoff, M.O., Eck, E.V., Park, C.M. (1972). A Model of Evolutionary Change in Proteins. In: Atlas of Protein Sequence and Structure, M.O. Dayhoff, ed., Vol. 5, pp. 89–99. Silver Spring, Maryland: National Biomedical Research Foundation
Deconinck, M., Peiffer, S., Depreter, J., Paul, C., Schnek, A.G., Leonis, J. (1975). BBA386, 567–575
Dumur, V., Dautrevaux, M., Han, K. (1976). BBA427, 759–761
Dwulet, F.E., Bogardt, R.A., Jones, B.N., Lehman, L.D. (1975). Biochemistry14, 5336–5443
Dwulet, F.E., Jones, B.N., Lehman, L.D., Gurd, F.R.N. (1977). Biochemistry16, 873–876
Emmens, M., Welling, G.W., Beintema, J.J. (1976). Biochem. J.157, 317–323
Finkelstein, A.V., Ptitsyn, O.B. (1971). J. Mol. Biol.62, 613–624
Gatlin, L.L. (1972). Information Theory and the Living System, New York: Columbia Univ. Press
Gatlin, L.L. (1974). J. Mol. Evol.3, 189–208
Gatlin, L.L. (1976). J. Mol. Evol.7, 185–195
Groen, G., Welling, G.W. Beintema, J.J. (1975). FEBS Lett.60, 300–304
Hartley, R.V. (1928). Bell System Techn. J.7, 535–563
Hase, T., Ohmiya, M., Matsubara, H., Mullinger, R.N., Rao, K.K., Hall, D.O. (1976a). Biochem. J.159, 55–63
Hase, T., Wada, K., Ohmiya, M., Matsubara, H., (1976b). J. Biochem.80, 993–999
Hase, T., Wakabayshi, S., Matsubara, H., Kerscher, L., Oesterhelt, D., Rao, K.K., Hall, D.O. (1977). FEBS Lett.77, 308–310
Hasegawa, M., Yano, T.A. (1975). Origins of Life6, 219–227
Hermann, J., Jollés, J., Buss, D.H., Jollés, P. (1973). J. Mol. Biol.79, 587–595
Holmquist, R. (1975). J. Mol. Evol.4, 277–306
Holmquist, R., Moise, H. (1975). J. Mol. Evol.6, 1–14
Hopfinger, A.J. (1972). Currents in Mod. Biol. Biosystems5, 38–42
Jollés, J., Schoentgen, F., Jollés, P., Prager, E.M., Wilson, A.C. (1976). J. Mol. Evol.8, 59–78
Jones, B.N., Vigna, R.A., Dwulet, F.E., Bogardt, R.A., Lehman, L.D., Gurd, F.R.N. (1976). Biochemistry15, 4418–4422
Jong, W.W. de, Gleaves, J.T., Boulter, D. (1977). J. Mol. Evol.10, 123–135
Kimura, M. (1968). Nature217, 624–626
King, J.L., Jukes, T.H. (1969). Science164, 788–798
Kullback, S. (1959). Information Theory and Statistics, New York: Wiley
Lehman, L.D., Dwulet, F.E., Bogardt, R.A., Jones, B.N., Gurd, F.R.N. (1977). Biochemistry16, 706–709
Levine, R.D., Ben-Shaul, A. (1977). In: Chemical and Biochemical Applications of Lasers, C.B. Moore, ed., Vol. II, pp. 145–197, London: Academic Press
Levine, R.D., Bernstein, R.B. (1974). Accts. Chem. Res.7, 393–400
Lin, K.D., Kim, V.K., Chernoff, A.J. (1976). Biochem. Genet.14, 427–440
Lyddiat, A., Boulter, D. (1976a). FEBS Lett.62, 85–88
Lyddiat, A., Boulter, D. (1976b). FEBS Lett.67, 331–334
Lyddiat, A., Boulter, D. (1977). Biochem. J.163, 333–338
Martinez, G., Rochat, H., Ducet, G. (1974). FEBS Lett.47, 212–217
Matsuda, G., Maita, T., Watanabe, B., Araya, A., Morokuma, K., Goodman, M., Prychodko, W. (1973). Hoppe-Seyler's Z. Physiol. Chem.354, 1153–1155
Nagano, K. (1973). J. Mol. Biol.75, 401–420
Ohta, T., Kimura, M. (1971a). J. Mol. Evol.1, 18–25
Ohta, T., Kimura, M. (1971b). Science174, 150–153
Reichert, T.A., Cohen, D.N., Wong, A.K.C. (1973). J. Theor. Biol.42, 245–261
Renyi, A. (1962). Wahrscheinlichkeitsrechnung. Berlin-Ost: Deutscher Verlag der Wissenschaften (in English 1970: Probability Theory, Amsterdam: North-Holland)
Romero-Herrera, A.E., Lehmann, H. (1974). BBA359, 236–241
Romero-Herrera, A.E., Lehmann, H., Fakes, W. (1975a). BBA379, 13–21
Romero-Herrera, A.E., Lehmann, H. (1975b), BBA393, 205–214
Romero-Herrera, A.E., Lehmann, H. (1975c). BBA400, 387–398
Romero-Herrera, A.E., Lehmann, H., Castillo, O. (1976a). BBA420, 387–396
Romero-Herrera, A.E., Lehmann, H., Castillo, O. (1976b). BBA439, 51–54
Rousseaux, J., Dautrevaux, M., Han, K. (1976). BBA439, 55–62
Schlögl, F. (1975). Z. PhysikB 20, 177–184
Shannon, C.E., Weaver, W. (1949). The Mathematical Theory of Communication, Univ. of Illinois Press, Urbana
Smith, T.F. (1969). Math. Biosciences4, 179–187
Stenzel, P. (1974). Nature252, 62–63
Takei, H., Ota, Y., Wu, K.C., Kiyohara, T., Matsuda, G. (1975). J. Biochem.77, 1345–1347
Tanaka, M., Haniu, M., Yasunobu, K.T., Evans, M.C.W., Rao, K.K. (1975). Biochemistry14, 1938–1943
Tentori, L., Vivaldi, G., Carta, S., Marinucci, M., Massa, A., Antonini, N.E., Brunori, M. (1973). I.J. Pept. Prot. Res.5, 187–200
Vogel, H. (1975). J. Mol. Evol.6, 271–283
Vogel, H. Zuckerkandl, E. (1971). In: Molecular Evolution, E. Schofeniels, ed., Vol. II, pp. 352–365
Wada, K., Hase, T., Tokunaga, H., Matsubara, H. (1975). FEBS Lett.55, 102–104
Welling, G.W., Groen, G., Beintema, J.J. (1975). Biochem. J.147, 505–511
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Coutelle, R., Hofacker, G.L. & Levine, R.D. Evolutionary changes in protein composition — evidence for an optimal strategy. J Mol Evol 13, 57–72 (1979). https://doi.org/10.1007/BF01732754
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DOI: https://doi.org/10.1007/BF01732754