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Age changes of spine density in posterior-anterior and lateral projections in normal women

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Abstract

Bone mineral density (BMD) was measured in 353 healthy white women using dual-energy X-ray absorptiometry (DXA). Measurements were made of both the posterior-anterior (PA) and lateral spine, as well as the proximal femur (neck and Ward's triangle). From age 50 to 80 years, the BMD of the PA spine and femur neck BMD had an 18% diminution (0.6%/year), and BMD of the lateral spine showed about a 35–40% decline (1.4%/year). The Ward's triangle region of the femur was not quite as decreased (30% or 1.1%/year). The BMD decrease associated with aging did not differ as much among sites when expressed relative to the intrapopulation variation rather than as a percentage. The Z-score for PA spine and femur neck BMD (-1.1) was significantly different than that for lateral spine BMD (-1.6); Ward's triangle was intermediate (-1.3), i.e., the lateral spine still showed the highest sensitivity to aging. However, the ability to detect age changes in an individual subject can be increased only if the precision error for lateral spine BMD is not increased to a greater extent than the sensitivity.

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References

  1. Mazess RB (1990) Bone densitometry for clinical diagnosis and monitoring. In: DeLuca HF, Mazess RB (eds) Osteoporosis physiological basis, assessment, and treatment. Elsevier, New York, pp 63–85

    Google Scholar 

  2. Sartoris DJH, Resnick D (1989) Dual-energy radiographic absorptiometry for bone densitometry: current status and perspective. AJR 152:241–246

    Google Scholar 

  3. Mazess RB, Chesnut CH III, McClung M, Genant H (1992) Enhanced precision with dual-energy x-ray absorptiometry. Calcif Tissue Int 51:14–17

    Google Scholar 

  4. Orwoll ES, Oviatt SK, Mann T (1990) The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men. J Clin Endocrinol Metab 70(4):1202–1207

    Google Scholar 

  5. Dawson-Hughes B, Dallal GE (1990) Effect of radiographic abnormalities on rate of bone decrease from the spine. Calcif Tissue Int 46:280–281

    Google Scholar 

  6. Reid IR, Evans MC, Ames R, Wattie DJ (1991) The influence of osteophytes and aortic calcification on spinal mineral density in postmenopausal women. J Clin Endocrinol Metab 72:1372–1374

    Google Scholar 

  7. Ross PD, Wasnich RD, Vogel JM (1987) Magnitude of artifact errors in spine dual photon absorptiometry measurements. In: Christiansen C, Johansen JS, Riis BJ (eds) Osteoporosis. Osteopress APS, Copenhagen, pp 389–391

    Google Scholar 

  8. Drinka PJ, DeSmet AA, Bauwens SF, Rogot A (1992) The effect of overlying calcification on lumbar bone densitometry. Calcif Tissue Int 50:507–510

    Google Scholar 

  9. Ito M, Hayashi K, Yamada M, Uetani M, Yakamura T (1993) Relationship of osteophytes to bone mineral density and spinal fracture in men. Radiology 189:497–502

    Google Scholar 

  10. Masud T, Langley S, Wiltshire P, Doyle DV, Spector TD (1993) Effect of spinal osteophytosis on bone mineral density measurements in vertebral osteoporosis. Br Med J 307:172–173

    Google Scholar 

  11. Jones CD, Laval-Jeantet AM, Laval-Jeantet MH, Genant HK (1987) Importance of measurement of spongious vertebral bone mineral density in the assessment of osteoporosis. Bone 8:201–206

    Google Scholar 

  12. Rupich R, Pacifici R, Griffin M, Vered I, Susman N, Avioli LV (1990) Lateral dual energy radiography: a new method for measuring vertebral bone density. A preliminary study. J Clin Endocrinol Metab 70(6):1768–1770

    Google Scholar 

  13. Uebelhart D, Duboeuf F, Meunier P, Delmas P (1990) Vertebral bone mineral density (BMD) measurement assessed by lateral dual-photon absorptiometry (DPA). J Bone Miner Res 5:525–531

    Google Scholar 

  14. Slosman DO, Rizzoli R, Donath A, Bonjour J-Ph (1990) Vertebral bone mineral density measured laterally by dual-energy x-ray absorptiometry. Osteoporosis Int 1:23–29

    Google Scholar 

  15. Mazess RB, Gifford CA, Bisek JP, Barden HS, Hanson JA (1991) DEXA measurements of spine density in the lateral projection. I. Methodology. Calcif Tissue Int 49:235–239

    Google Scholar 

  16. Souza ACA, Nakamura T, Shiraki M, Stergiopoulos K, Ouchi Y, Orimo H (1990) Measurement of vertebral body using dualenergy X-ray absorptiometry in lateral projection. In: Christiansen C, Overgaard K (eds) Osteoporosis 1990. Osteopress APS, Copenhagen, pp 640–642

    Google Scholar 

  17. Finkelstein JS, Cleary RL, Butler JP, Antonelli R, Mitlak BH, Deraska DJ, Zamora-Quezada JC, Neer RM (1994) A comparison of lateral versus anterior-posterior spine dual energy x-ray absorptiometry for the diagnosis of osteopenia. J Clin Endocrinol Metab 78:724–730

    Google Scholar 

  18. Norimatsu H, Kawanishi J (1993) Use of a rapid decrease in trabecular bone density in the early diagnosis of senile osteoporosis. Osteoporosis Int 3(suppl 1):S72–74

    Google Scholar 

  19. Peel NFA, Eastell R (1994) Diagnostic value of estimated volumetric bone mineral density of the lumbar spine in osteoporosis. J Bone Miner Res 9:317–320

    Google Scholar 

  20. Duboeuf F, Pomment R, Meunier PJ, Delmas PD (1994) Dual-energy x-ray absorptiometry of the spine in anteroposterior and lateral projections. Osteoporosis Int 4:110–116

    Google Scholar 

  21. Guglielmi G, Grimston SK, Fischer KC, Pacifici R (1994) Osteoporosis: diagnosis with lateral and posteroanterior dual x-ray absorptiometry compared with quantitative CT. Radiology 192: 845–850

    Google Scholar 

  22. Lilley J, Eyre S, Walters B, Heath DA, Mountford PJ (1994) An investigation of spinal bone mineral density measured laterally: a normal range for UK women. Br J Radiol 67:157–161

    Google Scholar 

  23. Reid IR, Evans MC, Stapleton J (1992) Lateral spine densitometry is a more sensitive indicator of glucocorticoid-induced bone loss. J Bone Miner Res 7:1221–1225

    Google Scholar 

  24. Mazess RB, Collick B, Trempe J, Barden HS, Hanson JA (1989) Performance evaluation of a dual-energy x-ray bone densitometer. Calcif Tissue Int 44:228–232

    Google Scholar 

  25. Favus MJ (1993) Bone density reference data. In: Favus MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 2nd ed. Raven Press, New York, pp 426–430

    Google Scholar 

  26. Larnach TA, Boyd SJ, Smart RC, Butler SP, Rohl PG, Diamond TH (1992) Reproducibility of lateral spine scans using dual energy x-ray absorptiometry. Calcif Tissue Int 51:255–258

    Google Scholar 

  27. del Rio L, Manubens M, Figuerola E (1992) Precision of lateral spine densitometry using DEXA. J Bone Miner Res 7 (suppl 1): S186

  28. Blake GM, Jagathesan T, Herd RJM, Fogelman I (1994) Dual x-ray absorptiometry of the lumbar spine: the precision of paired anteroposterior/lateral studies. Br J Radiol 67:624–630

    Google Scholar 

  29. Rupich RC, Griffin MG, Pacifici R, Avioli LV, Susman N (1992) Lateral dual-energy radiography: artifact error from rib and pelvic bone. J Bone Miner Res 7:97–101

    Google Scholar 

  30. Laitinen K, Valimaki M, Keto P (1991) Bone mineral density measured by dual-energy x-ray absorptiometry in healthy Finnish women. Calcif Tissue Int 48:224–231

    Google Scholar 

  31. Truscott JG, Oldroyd B, Simpson M, Stewart SP, Westmacott CF, Milner R, Horsman JA, Smith MA (1993) Variation in lumbar spine and femoral neck bone mineral measured by dual energy x-ray absorption: a study of 329 normal women. Br J Radiol 66:514–521

    Google Scholar 

  32. Blake GM, Jagathesan T, Herd RJM, Fogelman I (1994) A longitudinal study of supine lateral dual x-ray absorptiometry in peri- and post-menopausal women. In: Ring EFJ, Elvins DM, Bhalla AK (eds) Current research in osteoporosis and bone mineral measurement III. The British Institute of Radiology, London, pp 55–56

    Google Scholar 

  33. Bjarnason K, Hassager C, Christiansen C (1994) Lateral DEXA of the lumbar spine is not superior to the AP projection for the diagnosis and follow-up on bone loss. J Bone Miner Res 9(suppl 1): S274

  34. Griffin MG, Rupich RC, Avioli LV, Pacifici R (1991) A comparison of dual energy radiography measurements at the lumbar spine and proximal femur for the diagnosis of osteoporosis. J Clin Endocrinol Metab 73:1164–1169

    Google Scholar 

  35. Myers BS, Arbogast KB, Lobaugh B, Harper KD, Richardson WJ, Drezner MK (1994) Improved assessment of lumbar vertebral body strength using supine lateral dual-energy x-ray absorptiometry. J Bone Miner Res 9:687–693

    Google Scholar 

  36. Wilson CR, Yoganandan N, Collier BD (1992) The relationship between frontal and lateral DPA measurement of the lumbar spine and the strength of the vertebral body. In: Ring EFJ (ed) Current research in osteoporosis and bone mineral measurement II. The British Institute of Radiology, London, p 25

    Google Scholar 

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Authors and Affiliations

  1. LUNAR Corporation, 313 West Beltline Highway, 53713, Madison, Wisconsin, USA

    R. B. Mazess & H. S. Barden

  2. Joint Implant Surgeons, 720 East Broad Street, 43215, Columbus, Ohio, USA

    R. W. Eberle

  3. Monarch Foundation, 400 Oak Street, Suite B3, 45219, Cincinnati, Ohio, USA

    M. Drue Denton

Authors
  1. R. B. Mazess
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  2. H. S. Barden
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  3. R. W. Eberle
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  4. M. Drue Denton
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Mazess, R.B., Barden, H.S., Eberle, R.W. et al. Age changes of spine density in posterior-anterior and lateral projections in normal women. Calcif Tissue Int 56, 201–205 (1995). https://doi.org/10.1007/BF00298610

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  • DOI: https://doi.org/10.1007/BF00298610

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