Summary
Several laboratories, including our own, have investigated the physiology of bone blood flow by perfusion of the tibia via the nutrient artery. Any damage caused to the nerve supply by cannulation of the artery might affect the results. The possible effect of such damage was investigated by measuring blood flow to the dog tibia using a microsphere technique, before and after sympathectomy. No effect was found and the tibial nutrient artery is therefore a suitable vessel for perfusion when estimating nutrient exchange in bone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Drinker CK, Drinker KR (1916) A method for maintaining an artificial circulation through the tibia of the dog, with a demonstration of the vasomotor control of the marrow vessels. Am J Physiol 40:514–521.
Davies DR, Bassingthwaighte JB, Kelly PJ (1975) Transcapillary exchange of85Sr and sucrose in the canine tibia. J Bone Joint Surg 57A:572
Bloom JP, Fitzgerald RH Jr, Washington JA II, Kelly PJ (1980) The transcapillary passage and interstitial fluid concentration of penicillin in canine bone. J Bone Joint Surg 62:1168–1172
McCarthy ID, Hughes SPF, Orr JS (1980) An experimental model to study the relationship between blood flow and uptake for bone-seeking radionuclides in normal bone. Clin Phys Physiol Meas 1:135–143
McCarthy ID, Hughes SPF (1983) The role of skeletal blood flow in determining the uptake of99mTc methylene diphosphonate. Calcif Tissue Int 35:508–511
Duncan CP, Shim SS (1977) The autonomic nerve supply of bone. An experimental study of the intraosseous adrenergic nervi vasorum in the rabbit. J Bone Joint Surg 59B:323–330
Heymann MA, Payne BD, Hoffman JIE, Rudolph AM (1977) Blood flow measurements with radionuclide-labelled particles. Prog Cardiovasc Dis 20:55–79
Sagar VV, Piccone JM, Charkes ND (1979) Studies of skeletal tracer kinetics. III99mTc(Sn) methylene diphosphonate uptake in the canine tibia as a function of blood flow. J Nucl Med 20:1257–1261
Trotman NM, Kelly WD (1963) The effects of sympathectomy on blood flow to bone. J Am Med Assn 183:121–122
McElfesh EC, Kelly PJ (1974) Effect of sympathectomy and sciatic nerve stimulation on bone blood flow. Surg Forum 25:483–485
Lowenstein JM, Pauporte J, Richards V, Davison R (1958) Effects of sympathectomy on blood turnover rates in muscle and bone. Surgery 43:768–773
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Davies, R., Tothill, P., Hooper, G. et al. The early effects of sympathectomy on bone blood flow. Calcif Tissue Int 36, 622–624 (1984). https://doi.org/10.1007/BF02405377
Issue Date:
DOI: https://doi.org/10.1007/BF02405377