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Hyaluronate in articular cartilage: Age-related changes

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Summary

Articular cartilage of fetal calves, calves, and steers together with normal and osteoarthrotic human cartilage was analyzed for hyaluronate. The hyaluronate content increased with maturation in healthy tissue, particularly in regions of maximum contact, but was low in diseased cartilage.

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References

  1. Bjelle, A.D., Antonopoulos, C.A., Engfeldt, B., Hjertquist, S.-O.: Fractionation of glycosaminoglycans of human articular cartilage on Ecteola cellulose in ageing and in osteoarthrosis. Calcif. Tissue Res.8, 237–246 (1972)

    PubMed  Google Scholar 

  2. Lemperg, R., Larsson, S.-E., Hjertquist, S.-O.: The glycosaminoglycans of bovine articular cartilage. I. Concentration and distribution in different layers in relation to age. Calcif. Tissue Res.15, 237–251 (1974)

    PubMed  Google Scholar 

  3. Sweet, M.B.E., Thonar, E.J.-M.A., Immelman, A.R.: Regional distribution of water and glycosaminoglycan in immature articular cartilage. Biochim. Biophys. Acta500, 173–186 (1977)

    PubMed  Google Scholar 

  4. Sweet, M.B.E., Thonar, E.J.-M.A., Immelman, A.R., Solomon, L.: Biochemical changes in progressive osteoarthrosis. Ann. Rheum. Dis.36, 387–398 (1977)

    PubMed  Google Scholar 

  5. Scott, J.E.: Aliphatic ammonium salts in the assay of acidic polysaccharides from tissues. Methods Biochem. Anal.8, 145–197 (1960)

    PubMed  Google Scholar 

  6. Antonopoulos, C.A., Heinegard, D., Gardell, S.: Chromatography of glycosaminoglycans on Ecteola-cellulose columns. Biochim. Biophys. Acta148, 158–163 (1967)

    PubMed  Google Scholar 

  7. Larsson, S.-E., Ray, R.D., Kuettner, K.E.: Microchemical studies on acid glycosaminoglycans of the epiphyseal zones during endochondral ossification. Calcif. Tissue Res.13, 271–285 (1973)

    PubMed  Google Scholar 

  8. Seno, N., Anno, K., Kondo, K., Nagase, S., Saito, S.: Improved method for electrophoretic separation and rapid quantitation of isomeric chondroitin sulphates on cellulose acetate strips. Anal. Biochem.37, 197–201 (1970)

    PubMed  Google Scholar 

  9. Lembach, K.J.: Enhanced synthesis and extracellular accumulation of hyaluronic acid during stimulation of quiescent human fibroblasts by mouse epidermal growth factor. J. Cell. Physiol.89, 277–288 (1976)

    PubMed  Google Scholar 

  10. Lindner, J.: Age dependent changes in cartilage. In H.G. Vogel (ed.): Connective Tissue and Ageing, pp. 85–90. Excerpta Medica, Amsterdam 1973

    Google Scholar 

  11. Breen, M., Johnson, R.L., Sittig, R.A., Weinstein, H.G., Veis, A.: The acidic glycosaminoglycans in human foetal development and adult life: cornea, sclera, and skin. Conn. Tissue Res.1, 291–303 (1972)

    Google Scholar 

  12. Szirmai, J.A.L., Glycosaminoglycans in umbilical cord. In E.A. Balazs, R.W. Jeanloz (eds.): The Amino Sugars, Vol. IIA, pp. 219–227. Academic Press, New York, 1965

    Google Scholar 

  13. Wusteman, F.S., Gillard, G.C.: Hyaluronic acid in elastic cartilage. Experientia33, 721–723 (1977)

    PubMed  Google Scholar 

  14. Hardingham, T.E., Adams, P.: A method for the determination of hyaluronate in the presence of other glycosaminoglycans and its application to human intervertebral disc. Biochem. J.159, 143–147 (1976)

    PubMed  Google Scholar 

  15. Wiebkin, O.W., Hardingham, T.E., Muir, H.: Hyaluronic acidproteoglycan interaction and the influence of hyaluronic acid on proteoglycan synthesis by chondrocytes from adult cartilage. In H.C. Slavkin, R.C. Greulich (eds.): Extracellular Matrix Influences on Gene Expression, pp. 209–223. Academic Press, New York 1975

    Google Scholar 

  16. Handley, C.J., Lowther, D.A.: Inhibition of proteoglycan biosynthesis by hyaluronic acid in chondrocytes in cell culture. Biochim. Biophys. Acta444, 69–74 (1976)

    PubMed  Google Scholar 

  17. Gramling, E., Niedermeier, W., Holley, H.L. Pigman, W.: Some factor affecting the interaction of hyaluronic acid with bovine-plasma albumin. Biochim. Biophys. Acta69, 552–558 (1963)

    PubMed  Google Scholar 

  18. Aoki, S.: Studies on sero-immunological differences between the synovial and cartilaginous tissues by means of the fluorescent antibody technique. Bull. Osaka Med. School10, 1–21 (1964)

    Google Scholar 

  19. Ogston, A.G.: The biological function of the glycosaminoglycans. In E.A. Balazs (ed.): Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 3, pp. 1231–1240. Academic Press, London, 1970

    Google Scholar 

  20. Bayliss, M.T., Ali, S.Y.: Isolation of proteoglycans from human articular cartilage. Biochem. J.169, 123–132 (1978)

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Orthopaedic Surgery and Biochemistry, University of the Witwatersrand, Johannesburg, South Africa

    E. J. -M. A. Thonar, M. B. E. Sweet, A. R. Immelman & G. Lyons

Authors
  1. E. J. -M. A. Thonar
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  2. M. B. E. Sweet
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  3. A. R. Immelman
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  4. G. Lyons
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Thonar, E.J.M.A., Sweet, M.B.E., Immelman, A.R. et al. Hyaluronate in articular cartilage: Age-related changes. Calc. Tis Res. 26, 19–21 (1978). https://doi.org/10.1007/BF02013228

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  • DOI: https://doi.org/10.1007/BF02013228

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