Summary
Lungs from cortisone treated rats were examined under the electron microscope. Major alterations appeared in the mitochondria; changes in the endoplasmatic reticulum and basement membranes were also observed. Isolated features noticed were extracellular and intracellular lattice structures, crystalloid formation, swelling of the Golgi apparatus and nuclear damage.
Similar content being viewed by others
References
Boland, E.W.: Clinical use of cortisone, hydrocortisone and corticotropin. J. Amer. Med. Ass. 150, 1281–1288 (1952).
Reynolds, E.S.: The use of lead cotrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963).
Schlipkoeter, H.W., u. E. Lindner: Submikroskopische Membranstrukturen in silikotischen Quarzgranulomen der Rattenlunge. Z. Hyg. Infekt.-Kr. 145, 574–586 (1959).
Sollmann, T.: Manual of Pharmacology, Eight edit., p. 588. Philadelphia and London: W.B.Saunders Comp. 1957.
Ueberberg, H. Elektronenmicroskopische Untersuchungen an der Nebennierenrinde der cortisonbehandelten Ratte. European Reg. Conf. on E.M., 1960, p. 857–861.
Yoshimura and Vrie, as cit. by K. Kurosumi: Electron microscopic analysis of secretion mechanism. Int. Rev. Cytol. 11, 1–124 (1961).
Author information
Authors and Affiliations
Additional information
This investigation was supported in part by an American Cancer Society Institutional Grant.
Rights and permissions
About this article
Cite this article
Sun, C.N., Saueressig, S. Subcellular alterations in cortisone treated rat lungs. Zeitschrift für Zellforschung 67, 718–722 (1965). https://doi.org/10.1007/BF00340333
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00340333