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Uptake and utilization of human polymorphonuclear leukocyte granule myeloperoxidase by mouse peritoneal macrophages

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Summary

Functional myeloperoxidase contained in granules of polymorphonuclear neutrophil leukocytes or in fixed whole cells can be endocytosed by mouse peritoneal macrophages. Acquired myeloperoxidase was distributed in what we considered to be the secondary lysosomal system and, following a phagocytic stimulation, was delivered to newly formed phagosomes containing the targets.

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Authors and Affiliations

  1. Periodontal Disease Research Center, Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA

    K. -P. Leung Ph.D.

  2. Department of Molecular and Cellular Biology, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA

    M. B. Goren

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  1. K. -P. Leung Ph.D.
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  2. M. B. Goren
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Leung, K.P., Goren, M.B. Uptake and utilization of human polymorphonuclear leukocyte granule myeloperoxidase by mouse peritoneal macrophages. Cell Tissue Res. 257, 653–656 (1989). https://doi.org/10.1007/BF00221477

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  • DOI: https://doi.org/10.1007/BF00221477

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