Summary
The presence of a nerve located just caudal to the pineal gland in the mid-sagittal plane is demonstrated in sheep and rabbit fetuses. This nerve lies freely in the subarachnoid space and extends from the pineal gland to a region of the CNS located dorsal to the rostralmost part of the subcommissural organ (SCO). In rabbit fetuses the nerve is observed on days 23 and 24 of gestation; we suggest that it is an ontogenetic equivalent to the pineal nerve of anuran amphibians. The developmental fate of the mammalian fetal pineal nerve is discussed.
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Böttger, W. V., Böttger, E.-M.: Degenerationstudien am Nervus pinealis von Rana esculenta L. nach stirnorgannaher und -ferner Durchtrennung. Z. Zellforsch. 136, 365–391 (1973)
David, G. F. X., Herbert, J.: Experimental evidence for a synaptic connection between habenula and pineal ganglion in the ferret. Brain Res. 64, 327–343 (1973)
David, G. F. X., Herbert, J., Wright, G. D. S.: The ultrastructure of the pineal ganglion in the ferret. J. Anat. (Lond.) 115, 79–97 (1973)
Diederen, J. H. B.: The subcommissural organ of Rana temporaria I. A cytological, cytochemical, cyto-enzymological and electron-microscopical study. Z. Zellforsch. 111, 379–403 (1970)
Gardner, J. H.: Innervation of pineal gland in hooded rat. J. comp. Neurol. 99, 319–329 (1953)
Hafeez, M. A., Zerihun, L.: Studies on central projections of the pineal nerve tract in rainbow trout, Salmo gairdneri Richardson, using cobalt chloride iontophoresis. Cell Tiss. Res. 154, 485–510 (1974)
Kappers, J. Ariëns: The development, topographical relations and innervation of the epiphysis cerebri in the albino rat. Z. Zellforsch. 52, 163–215 (1960)
Kappers, J. Ariëns: Survey of the innervation of the epiphysis cerebri and the accessory pineal organ of vertebrates. Progr. Brain Res. 10, 87–151 (1965)
Kenny, G. C. T.: The “nervus conarii” of the monkey. An experimental study. J. Neuropath, exp. Neurol. 20, 563–570 (1961)
Kolmer, W., Löwy, R.: Beiträge zur Physiologie der Zirbeldrüse. Pflügers Arch. ges. Physiol. 196, 1–14 (1922)
Le Gros Clark, W. E.: The nervous and vascular relations of the pineal gland. J. Anat. (Lond.) 74, 471–492 (1940)
Menaker, M., Oksche, A.: The avian pineal organ. In: Avian biology, Vol. 4 (eds.: Donald S. Farner and James R. King), p. 79–118. New York and London: Academic Press 1974
Møllgård, K., Møller, M.: On the innervation of the human fetal pineal gland. Brain Res. 52, 428–432 (1973)
Paul, E.: Innervation und zentralnervöse Verbindungen des Frontalorgans von Rana temporaria und Rana esculenta. Faserdegeneration nach operativer Unterbrechung des Nervus pinealis. Z. Zellforsch. 128, 504–511 (1971)
Pines, L.: Über die Innervation der Epiphyse. Z. ges. Neurol. Psychiat. 111, 356–369 (1927)
Rodríguez, E. M.: Ependymal specializations. III. Ultrastructural aspects of the basal secretion of the toad subcommissural organ. Z. Zellforsch. 111, 32–50 (1970)
Romijn, H. J.: Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.), with some functional considerations. Thesis (Amsterdam) 1972
Romijn, H. J.: Parasympathetic innervation of the rabbit pineal gland. Brain Res. 55, 431–436 (1973)
Scharenberg, K., Liss, L.: The histologic structure of the human pineal body. Progr. Brain Res. 10, 193–217 (1965)
Ueck, M., Vaupel-von Harnack, M., Morita, Y.: Weitere experimentelle und neuroanatomische Untersuchungen an den Nervenbahnen des Pinealkomplexes der Anuren. Z. Zellforsch. 116, 250–274 (1971)
Wake, K., Ueck, M., Oksche, A.: Acetylcholinesterase-containing nerve cells in the pineal complex and subcommissural area of the frogs, Rana ridibunda and Rana esculenta. Cell Tiss. Res. 154, 423–442 (1974)
Wurtman, R. J., Axelrod, J., Kelly, D. E.: The pineal. New York: Academic press 1968
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Acknowledgement: The authors wish to thank Drs. N. Saunders, J. Reynolds and M. Reynolds, Department of Physiology, University College, London, for providing the sheep material.
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Møller, M., Møllgård, K. & Kimble, J.E. Presence of a pineal nerve in sheep and rabbit fetuses. Cell Tissue Res. 158, 451–459 (1975). https://doi.org/10.1007/BF00220212
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DOI: https://doi.org/10.1007/BF00220212