Summary
The ultrastructure of glycerol extracted thrombocyte models was studied before and after incubation with ATP and under the influence of Salyrgan as inhibitor of contraction. The contractile system of the thrombocytes—thrombosthenin—consists of a spatial network of 50 Å wide thrombosthenin A and 100–120 Å wide thrombosthenin M filaments. At rest, the contractile system is arranged in a marginal zone. The ATP-induced contraction led to a concentric condensation of the network which resulted in a central cluster of cell organelles and at a later stage, disruption of the plasma membrane and release of the thrombocyte granules. All these changes which also occur during the formation of the hemostatic plug in vivo are therefore attributed to the reaction of the contractile protein.
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Keyserlingk, D.G., Struwe, K. The ultrastructural arrangement of thrombosthenin in glycerol extracted thrombocytes. Z.Zellforsch 138, 557–567 (1973). https://doi.org/10.1007/BF00572296
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DOI: https://doi.org/10.1007/BF00572296