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Yeast artificial chromosome mapping of the cystinosis locus on chromosome 17p by fluorescence in situ hybridization

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Abstract

The gene locus for cystinosis has been mapped between markers D17S1583 and D17S1584 on the short arm of chromosome 17. Using markers encompassing the cystinosis region, we assigned different yeast artificial chromosome (YAC) clones previously identified by sequence tagged site (STS) screening to 17p13.3. Three of the clones hybridized to the target 17p gene region; one of these was chimeric, hybridizing both to chromosomes 3p and 5q; two of the YACs did not contain sequences of 17p13.3. Our physical mapping has identified candidate YACs as a first step towards a positional cloning approach.

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Authors and Affiliations

  1. Department of Human Genetics, Biozentrum/Am Hubland, D-97074 Würzburg, Germany Tel.: +49 931 8884077; Fax: +49 931 8884069, , , , , , DE

    Ingrid Stec, Michael R. Koehler & M. Schmid

  2. Klinik und Poliklinik für Kinderheilkunde, Universität Münster, Albert-Schweitzer Strasse 33, D-48149 Münster, Germany, , , , , , DE

    Ulrike Peters, Erik Harms & Thomas Deufel

Authors
  1. Ingrid Stec
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  2. Ulrike Peters
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  3. Erik Harms
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  4. Michael R. Koehler
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  5. M. Schmid
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  6. Thomas Deufel
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Received: 28 February 1996 / Revised: 3 May 1996

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Stec, I., Peters, U., Harms, E. et al. Yeast artificial chromosome mapping of the cystinosis locus on chromosome 17p by fluorescence in situ hybridization. Hum Genet 98, 321–322 (1996). https://doi.org/10.1007/s004390050215

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  • DOI: https://doi.org/10.1007/s004390050215

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