A new XmnI polymorphism in the regulatory region of the corticotropin releasing hormone gene

Abstract

We describe the first polymorphism in the 5′ flanking region of the corticotropin releasing hormone (CRH) gene. DNA sequencing analysis identified a T → G base substitution in the 5′ flanking region of the gene. This substitution leads to the loss of an XmnI site at position 255 of the Genbank entry X67661. The frequency analysis in 32 Caucasians revealed that it is a rare polymorphism, with only three observed heterozygous individiuals for this polymorphism.