Summary
The gene coding for the type I (p55) tumor necrosis factor receptor (TNF-R1) has been localized on human chromosome 12, band 12p13.2, by in situ hybridisation using a biotinylated genomic probe.
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References
Aggarwal BB, Eessalu TE, Hass PE (1985) Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon. Nature 318:665–667
Berger R, Bernheim A, Le Coniat M, Vecchione D, Pacot A, Daniel M-T, Flandrin G (1986) Abnormalities of the short arm of chromosome 12 in acute nonlymphocytic leukemia and dysmyelopoietic syndrome. Cancer Genet Cytogenet 19:281–289
Bernheim A, Berger R (1981) A simple method for improving the reproducibility of the R-banding technique. Hum Genet 57: 432–433
Beutler B, Cerami A (1988) Tumor necrosis, cachexia, shock and inflammation: a common mediator. Annu Rev Biochem 75: 505–518
Camargo M, Cervenka J (1980) Pattern of chromosomal replication in synchronized lymphocytes. I. Evaluation and application of the methotrexate block. Hum Genet 54:47–53
Camargo M, Cervenka J (1982) Patterns of DNA replication of human chromosomes. II. Replication map and replication model. Am J Hum Genet 34:757–780
Cherif D, Julier C, Delattre O, Derré J, Lathrop GM, Berger R (1990) Simultaneous localization of cosmids and chromosome R-banding by fluorescence microscopy: application to regional mapping of human chromosome 11. Proc Natl Acad Sci USA 87:6639–6643
Engelmann H, Novick D, Wallach D (1990) Two tumor necrosis factor-binding proteins purified from human urine. J Biol Chem 265:1531–1536
Hohmann H, Remy R, Brockhaus M, van Loon APGM (1989) Two different cell types have different major receptors for human tumor necrosis factor (TNF-α). J Biol Chem 264:14927–14934
Johnson GD, Nogueira C de, Aranjo JGM (1981) A simple method for reducing the fading of immunofluorescence during microscopy. J Immunol Methods 43:349–350
Jonveaux P, Le Coniat M, Derré J, Vecchione D, Berger R (1991) Loss of genetic material from the short arm of chromosome 12 is a frequent secondary abnormality in non-Hodgkin's lymphoma. Hematol Pathol 5:21–26
Kievits T, Devilee P, Wiegant J, Wapenaar MC, Cornelisse CJ, van Ommen GJB, Pearson PL (1990) Direct nonradioactive in situ hybridization of somatic cell hybrid DNA to human lymphocyte chromosomes. Cytometry 11:105–109 Loetscher H, Pan Y-CE, Lahm H-W, Gentz R, Brockhaus M,
Tabuchi H, Lesslauer W (1990) Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell 61:351–359
Nophar Y, Kemper O, Brakebusch C, Engelmann H, Zwang R, Aderka D, Holtmann H, Wallach D (1990) Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor. EMBO J 9:3269–3278
Old LJ (1989) Tumor necrosis factor. Sci Am 258:41–49
Pinkel D, Straube T, Gray JW (1986) Cytogenetic analysis using qualitative, high sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 83:2934–2938
Raimondi SC, Williams DL, Callihan T, Peiper S, Rivera GK, Murphy SB (1986) Nonrandom involvement of the 12p12 break-point in chromosome abnormalities of childhood acute lymphoblastic leukemia. Blood 68:69–75
Ropers HH, Craig IW (1989) Report of the committee on the genetic constitution of chromosomes 12 and 13. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:259–279
Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GHW, Gatanaga T, Granger GA, Lentz R, Raab H, Kohr WJ, Goeddel DV (1990) Molecular cloning and expression of a receptor for human tumor necrosis factor. Cell 61:361–370
Shaul Y, Ziemer M, Garcia PG, Crawford R, Hsu H, Valenzuela D, Rutter WJ (1984) Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line. J Virol 51:776–787
Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, Dower SK, Cosman D, Gooswin RG (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248:1019–1023
Spence MA, Spurr NK, Field LL (1989) Report of the committee on the genetic constitution of chromosome 6. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:149–165
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Derré, J., Kemper, O., Cherif, D. et al. The gene for the type 1 tumor necrosis factor receptor (TNF-R1) is localized on band 12p13. Hum Genet 87, 231–233 (1991). https://doi.org/10.1007/BF00204191
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DOI: https://doi.org/10.1007/BF00204191