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Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy

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Summary

We have studied the genetic linkage of two markers, the apolipoprotein C1 (APOC1) gene and a cytochrome P450 (CYP2A) gene, in relation to the gene for myotonic dystrophy (DM). A peak lod score of 9.29 at 2 cM was observed for APOC1-DM, with a lod score of 8.55 at 4cM for CYP2A-DM. These two markers also show close linkage to each other (θ max = 0.05, Z max = 9.09). From examination of the genotypes of the recombinant individuals, CYP2A appears to map proximal to DM because in one recombinant individual CYP2A, APOC2 and CKMM had all recombined with DM. Evidence from another CYP2A-DM recombinant individual places CYP2A proximal to APOC2 and CKMM. Localisation of CYP2A on a panel of somatic cell hybrids also suggests that it is proximal to DM and APOC2/C1/E gene cluster.

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Authors and Affiliations

  1. Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK

    Kathryn V. Walsh, Helen G. Harley, J. David Brook, Shelley A. Rundle, Mansoor Sarfarazi, Peter S. Harper & Duncan J. Shaw

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  1. Kathryn V. Walsh
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  2. Helen G. Harley
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  3. J. David Brook
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  4. Shelley A. Rundle
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  5. Mansoor Sarfarazi
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  6. Peter S. Harper
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  7. Duncan J. Shaw
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Walsh, K.V., Harley, H.G., Brook, J.D. et al. Linkage relationships of the apolipoprotein C1 gene and a cytochrome P450 gene (CYP2A) to myotonic dystrophy. Hum Genet 85, 305–310 (1990). https://doi.org/10.1007/BF00206751

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  • DOI: https://doi.org/10.1007/BF00206751

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