Summary
The localization of human protein C gene on chromosome 2 was investigated by in situ hybridization using a partial cDNA for protein C. Silver-grain analysis indicates that the protein C gene is located on 2q13-q14.
References
Beckman RJ, Schmidt RJ, Santerre RF, Blutzsky GJ, Crabtree G, Long G (1985) The structure and evolution of a 461 aminoacid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNA. Nucleic Acids Res 13:5233–5247
Broeckmans AW, Bertina RM (1985) Protein C. In: Poller L (ed) Recent advances in blood coagulation. Churchill Livingstone, Edinburgh, pp 117–137
Calzolari E, Palazzi P, Aiello V, Mazzeo E, Perri P, Del Senno L, Patracchini P, Bernardi F (1987) De novo complex autosomal translocation involving chromosome 8, 13 and 15 in a girl with a sporadic retinoblastoma. Hum Genet 77:51–54
Foster DC, Yoshitake S, Davie EW (1985) The nucleotide sequence of the gene for human protein C. Proc Natl Acad Sci USA 82: 4673–4677
Kisiel W, Canfield WM, Ericsson LH, Davie EW (1977) Anticoagulant properties of bovine plasma protein C following activation by thrombin. Biochemistry 16:5824–5831
Morton NE, Bruns GA (1987) Report of the committee on the genetic constitution of chromosomes 1 and 2. (9th International Workshop on Human Gene Mapping). Cytogenet Cell Genet 46:102–130
Neurath H (1984) Evolution of proteolytic enzymes. Science 224: 350–357
Plutzky J, Hoskins JO, Long GL, Crabtree GR (1986) Evolution and organization of the human protein C gene. Proc Natl Acad Sci USA 83:546–550
Rocchi M, Roncuzzi L, Santamaria R, Archidiacono N, Dente L, Romeo G (1986) Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and α 1-acid glycoprotein to chromosome 9. Hum Genet 74:30–33
Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ (1985) Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci USA 82:1121–1125
Santamaria R, Roncuzzi L, Sbarra D, Cortese R, Romeo G (1985) Isolation and sequence of a cDNa coding for human protein C. In: Peschle C, Rizzoli C (eds) New trends in experimental haematology. Serono Symposia Review 7, pp 296–298
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Patracchini, P., Aiello, V., Palazzi, P. et al. Sublocalization of the human protein C gene on chromosome 2q13–q14. Hum Genet 81, 191–192 (1989). https://doi.org/10.1007/BF00293902
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DOI: https://doi.org/10.1007/BF00293902