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Characterization of chromosomes with hybrid genes for Hb Lepore-Washington, Hb Lepore-Baltimore, Hb P-Nilotic, and Hb Kenya

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Summary

This study concerns the characterization of chromosomes with hybrid genes for Hb Lepore-Washington (44 chromosomes), for Hb Lepore-Baltimore (5 chromosomes), for Hb P-Nilotic (8 chromosomes), and for Hb Kenya (7 chromosomes) by determining a relatively large number of restriction enzyme polymorphism. Two, and possibly three, different Hb Lepore-Washington chromosomes were identified by specific haplotypes, while the haplotype of the Hb Lepore-Baltimore chromosome had its own characteristic pattern. A likely conclusion is that the crossovers leading to the formation of these chromosomes have occurred as independent events within the populations. Chromosomes with the δβ-Lepore-Washington hybrid gene maintained specific characteristies (such as increased Hb F levels in heterozygotes, and high or low Gγ values in this Hb F) which have been observed in normal individuals with chromosomes having comparable haplotypes. Only one haplotype was observed for each of the chromosomes carrying either the βδ-P-Nilotic hybrid gene or the Aγβ hybrid gene of Hb Kenya.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, Laboratory of Protein Chemistry, Medical College of Georgia, 30912-3331, Augusta, GA, USA

    K. D. Lanclos, J. Patterson, J. B. Wilson, F. Kutlar & T. H. J. Huisman

  2. National Reference Laboratory for Hemoglobinopathies ZF, University of Skopje, P.F. 355, Skopje, Yugoslavia

    G. D. Efremov

  3. 2490 Keller Boulevard, Saint-Laurent, H4K 2P8, Montreal, Quebec, Canada

    S. C. Wong

  4. Servicio de Hematologia, Hospital Clinico de San Carlos, Madrid 3, Spain

    A. Villegas

  5. University of Nairobi Medical School, Kenyatta National Hospital, P.O. Box 30588, Nairobi, Kenya

    P. J. Ojwang

Authors
  1. K. D. Lanclos
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  2. J. Patterson
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  3. G. D. Efremov
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  4. S. C. Wong
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  5. A. Villegas
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  6. P. J. Ojwang
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  7. J. B. Wilson
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  8. F. Kutlar
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  9. T. H. J. Huisman
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Lanclos, K.D., Patterson, J., Efremov, G.D. et al. Characterization of chromosomes with hybrid genes for Hb Lepore-Washington, Hb Lepore-Baltimore, Hb P-Nilotic, and Hb Kenya. Hum Genet 77, 40–45 (1987). https://doi.org/10.1007/BF00284711

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  • DOI: https://doi.org/10.1007/BF00284711

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