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Identification and function of serologically detectable H-Y antigen

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References

  • Bennett D, Mathieson BJ, Scheid M, Yanagisawa K, Boyse EA, Wachtel S, Cattanach BM (1977) Serological evidence for H-Y antigen in Sxr, XX sex-reversed phenotypic males. Nature 265: 255–257

    Google Scholar 

  • Billingham RE, Hings IM (1981) The H-Y antigen and its role in natural transplantation. Hum Genet 58:9–17

    Google Scholar 

  • Chang CY (1953) Parabiosis and gonad transplantation in Xenopus laevis Daudin. J Exp Zool 123:1–28

    Google Scholar 

  • Ciccarese S, Massari S, Guanti G (1982) Sex behaviour is independent of H-Y antigen constitution. Hum Genet 60:371–372

    Google Scholar 

  • Cleve H (1981) H-Y antigen and sex determination. In: Peeters H (ed) Protides of the biological fluids (The tenth Arne Tiselius Memorial Lecture), vol 29. Pergamon Press, Oxford New York, pp 3–12

    Google Scholar 

  • Coulombre JL, Russell ES (1954) Analysis of the pleiotropism at the W locus in the mouse. The effects of W and Wv substitution upon postnatal development of germ cells. J Exp Zool 126:277–291

    Google Scholar 

  • de la Chapelle A, Koo GC, Wachtel SS (1978) Recessive sex-determining genes in human XX male syndrome. Cell 15:837–842

    Google Scholar 

  • Eicher W, Spoljar M, Cleve H, Murken JD, Richter K, Stengel-Rutkowski S (1979) H-Y antigen in transsexuality. Lancet II:1137–1138

    Google Scholar 

  • Eichwald EJ, Silmser CR (1955) Communication. Transplant Bull 2: 148–149

    Google Scholar 

  • Engel W, Pfäfflin F, Wiedeking C (1980) H-Y antigen in transsexuality, and how to explain testis differentiation in H-Y antigen-negative males and ovary differentiation in H-Y antigen-positive females. Hum Genet 55:315–319

    Google Scholar 

  • Engel W, Klemme B, Ebrecht A (1981) Serological evidence for H-Y antigen in XO female mice. Hum Genet 57:68–70

    Google Scholar 

  • Fellous M, Günther E, Kemler R, Wiels J, Berger R, Guenet JL, Jakob H, Jacob F (1978) Association of the H-Y male antigen with β2-microglobulin on human lymphoid and differentiated mouse teratocarcinoma cell lines. J Exp Med 148:58–70

    Google Scholar 

  • Fraccaro M, Tiepolo L, Zuffardi O, Chiumello G, Di Natale B, Gargantini L, Wolf U (1979) Familial XX true hermaphroditism and the H-Y antigen. Hum Genet 48:45–52

    Google Scholar 

  • Galbraith GMP, Galbraith RM, Faulk WP, Wachtel SS (1978) Detection of H-Y antigen by fluorescence microscopy. Transplantation 26: 25–27

    Google Scholar 

  • Goldberg EH, Boyse EA, Bennett D, Scheid M, Carswell EA (1971) Serological demonstration of H-Y (male) antigen on mouse sperms. Nature 232:478–480

    Google Scholar 

  • Goodfellow PN, Andrews PW (1982) Sexual differentiation and H-Y antigen. Nature 295:11–13

    Google Scholar 

  • Haseltine FP, Genel M, Crawford JD, Breg WR (1981) H-Y antigen negative patients with testicular tissue and 46,XY karyotype. Hum Genet 57:265–268

    Google Scholar 

  • Jost A (1979) Basic sexual trends in the development of vertebrates. Ciba Foundation Symposium 62, Excerpta Medica, Elsevier/North-Holland, Amsterdam, pp 5–7

    Google Scholar 

  • Koo GC (1981) Serology of H-Y antigen. Hum Genet 58:18–20

    Google Scholar 

  • Koo GC, Varano A (1981) Inhibition of H-Y cell-mediated cytolysis by monoclonal H-Y-specific antibody. Immunogenetics 14:183–188

    Google Scholar 

  • Macintyre MN (1956) Effect of the testis on ovarian differentiation in heterosexual embryonic rat gonad transplants. Anat Rev 124: 27–46

    Google Scholar 

  • Mangoushi MA (1975) Scrotal allografts of fetal ovaries. J Anat 120: 595–599

    Google Scholar 

  • Melvold RW, Kohn HI, Yerganian G, Fawcett DW (1977) Evidence suggesting the existence of two H-Y antigens in the mouse. Immunogenetics 5:33–41

    Google Scholar 

  • Merchant-Larios H (1976) The role of germ cells in the morphogenesis and cytodifferentiation of the rat ovary. In: Müller-Bérat et al (eds) Progress in differentiation research. North Holland Publishing Comp, Amsterdam, pp 453–462

    Google Scholar 

  • Müller U (1980) Testis determining H-Y antigen and the induction of the HCG receptor. In: Segal SJ (ed) Chorionic gonadotropin. Plenum Press, New York, pp 371–382

    Google Scholar 

  • Müller U (1981) Immunological and functional aspects of H-Y antigen. Hum Genet 58:29–33

    Google Scholar 

  • Müller U, Bross K (1979) A highly sensitive peroxidase-antiperoxidase method for detection of H-Y antigen on cultivated human fibroblasts. Hum Genet 52:143–147

    Google Scholar 

  • Müller U, Wolf U (1979) Cross-reactivity to mammalian anti-H-Y antiserum in teleostean fish. Differentiation 14:185–187

    Google Scholar 

  • Müller U, Urban E (1981a) Reaggregation of rat gonadal cells in vitro: experiments on the function of H-Y antigen. Cytogenet Cell Genet 31:104–107

    Google Scholar 

  • Müller U, Urban E (1981b) An oocyte-specific antigen and its possible role in the organization of the ovarian follicle of the rat. Differentiation 20:274–277

    Google Scholar 

  • Müller U, Aschmoneit I, Zenzes MT, Wolf U (1978a) Binding studies of H-Y antigen in rat tissues. Indications for a gonad-specific receptor. Hum Genet 43:151–157

    Google Scholar 

  • Müller U, Siebers JW, Zenzes MT, Wolf U (1978b) The testis as a secretory organ for H-Y antigen. Hum Genet 45:209–213

    Google Scholar 

  • Müller U, Wolf U, Siebers JW, Günther E (1979a) Evidence for a gonad-specific receptor for H-Y antigen: Binding of exogenous H-Y antigen to gonadal cells is independent of β2-microglobulin. Cell 17:331–335

    Google Scholar 

  • Müller U, Zenzes MT, Wolf U, Engel W, Weniger JP (1979b) Appearance of H-W (H-Y) antigen in the gonads of oestradiol sex-reversed male chicken embryos. Nature 280:142–144

    Google Scholar 

  • Müller U, Guichard A, Reyss-Brion M, Scheib D (1980a) Induction of H-Y antigen in the gonads of male quail embryos by diethyl-stilbestrol. Differentiation 16:129–133

    Google Scholar 

  • Müller U, Mayerova A, Siebers JW, Wolf U (1980b) Phenotypic conversion of human erythrocytes by H-Y antigen. Hum Genet 56: 177–181

    Google Scholar 

  • Müller U, Singh L, Grund S, Jones KW (1982) Ovarian cells participate in the formation of tubular structures in mouse/rat heterosexual gonadal co-cultures: A direct demonstration by in situ hybridization. Differentiation (to be published)

  • Nagai Y, Ciccarese S, Ohno S (1979) The identification of human H-Y antigen and testicular transformation induced by its interaction with the receptor site of bovine fetal ovarian cells. Differentiation 13: 155–164

    Google Scholar 

  • Ohno S, Nagai Y, Ciccarese S (1978) Testicular cells lysostripped of H-Y antigen organize ovarian follicle-like aggregates. Cytogenet Cell Genet 20:351–364

    Google Scholar 

  • Pechan P, Wachtel SS, Reinboth R (1979) H-Y antigen in the teleost. Differentiation 14:189–192

    Google Scholar 

  • Scheid M, Boyse EA, Carswell EA, Old LJ (1972) Serologically demonstrable alloantigens of mouse epidermal cells. J Exp Med 135: 938–955

    Google Scholar 

  • Selden JR, Wachtel SS, Koo GC, Haskins ME, Patterson DF (1978) Genetic basis of XX male syndrome and XX true hermaphroditism. Science 201:644–646

    Google Scholar 

  • Shalev A, Short RV, Hamerton JL (1980) Immunogenetics of sex determination in the polled goat. Cytogenet Cell Genet 28:195–202

    Google Scholar 

  • Silvers KW, Gasser DL, Eicher EM (1982) H-Y antigen, serologically detectable male antigen and sex determination. Cell 28:439–440

    Google Scholar 

  • Simpson E, Gordon RD (1977) Responsiveness to H-Y antigen, Ir gene complementation and target cell specificity. Immunol Rev 35: 59–75

    Google Scholar 

  • Simpson E, Chandler P, Pole D (1981) A model of T-cell unresponsiveness using the male-specific antigen, H-Y. Cell Immunol 62: 251–257

    Google Scholar 

  • Simpson E, McLaren A, Chandler P (1982) Evidence for two male antigens in mice. Immunogenetics 15:609–614

    Google Scholar 

  • Spoljar M, Eicher W, Eiermann W, Cleve H (1981) H-Y antigen in different tissues from transsexuals. Hum Genet 57:52–57

    Google Scholar 

  • Tokuda S, Arrington T, Goldberg EH, Richey J (1978) Simpler technique for serological detection of H-Y antigen on mouse lymphocytes. Nature 267:433–434

    Google Scholar 

  • Urban E, Zenzes MT, Müller U, Wolf U (1981) Cell reorganization in vitro of heterosexual gonadal cocultures. Differentiation 18: 161–168

    Google Scholar 

  • Wachtel SS (1981) Conservatism of the H-Y/H-W receptor. Hum Genet 58:54–58

    Google Scholar 

  • Wachtel SS, Hall JL (1979) H-Y binding in the gonad: inhibition of the fetal ovary. Cell 17:327–329

    Google Scholar 

  • Wachtel SS, Koo GC, Boyse EA (1975) Evolutionary conservation of H-Y (‘male’) antigen. Nature 254:270–272

    Google Scholar 

  • Wachtel SS, Koo GC, Breg WR, Thaler TH, Dillard GM, Rosenthal IM, Dosik H, Gerald PS, Spengler P, New M, Lieber E, Miller OJ (1976) Serologic detection of a Y linked gene in XX males and XX true hermaphrodites. N Engl J Med 295:750–754

    Google Scholar 

  • Wachtel SS, Basrur P, Koo GC (1978) Recessive male-determining genes. Cell 15:279–281

    Google Scholar 

  • Wachtel SS, Bresler PA, Koide SS (1980a) Does H-Y antigen induce the heterogametic ovary? Cell 20:859–864

    Google Scholar 

  • Wachtel SS, Hall JL, Müller U, Chaganti RSK (1980b) Serum-borne H-Y antigen in the fetal bovine freemartin. Cell 21:917–926

    Google Scholar 

  • Wachtel SS, Koo GC, Breg WR, Genel M (1980c). H-Y antigen in X,i(Xq) gonadal dysgenesis: Evidence of X-linked genes in testicular differentiation. Hum Genet 65:183–187

    Google Scholar 

  • Wiberg U, Mayerova A, Müller U, Fredga K, Wolf U (1982) X-linked genes of the H-Y antigen system in the wood lemming (Myopus schisticolor). Hum Genet 60:163–166

    Google Scholar 

  • Wolf U (1979) XY gonadal dysgenesis and the H-Y antigen. Hum Genet 47:269–277

    Google Scholar 

  • Wolf U, Fraccaro M, Mayerova A, Hecht T, Maraschino P, Hameister H (1980a) A gene controlling H-Y antigen on the X chromosome. Tentative assignment by deletion mapping to Xp223. Hum Genet 54:149–154

    Google Scholar 

  • Wolf U, Fraccaro M, Mayerova A, Hecht T, Zuffardi O, Hameister H (1980b) Turner syndrome patients are H-Y positive. Hum Genet 54:315–318

    Google Scholar 

  • Zaborski P, Dorizzi M, Pieau C (1979) Sur l'utilisation de sérum anti-H-Y de Souris pour la détermination du sexe génétique chez Emys orbicularis L. CR Acad Sci [D] (Paris) 288:353–354

    Google Scholar 

  • Zaborski P, Guichard A, Scheib D (1981) Transient expression of H-Y antigen in quail ovotestis following early diethylstilbestrol (DES) treatment. Biol Cell 41:113–122

    Google Scholar 

  • Zenzes MT, Müller U, Aschmoneit I, Wolf U (1978a) Studies on H-Y antigen in different cell fractions of the testis during pubescence. Immature germ cells are H-Y negative. Hum Genet 45:297–303

    Google Scholar 

  • Zenzes MT, Wolf U, Engel W (1978b) Organization in vitro of ovarian cells into testicular structures. Hum Genet 44:333–338

    Google Scholar 

  • Zenzes MT, Wolf U, Günther E, Engel W (1978c) Studies on the function of H-Y antigen: dissociation and reorganization experiments on rat gonadal tissue. Cytogenet Cell Genet 20:365–372

    Google Scholar 

  • Zenzes MT, Urban E, Wolf U (1980) Mammalian cross-reactive H-Y antigen induces sex-reversal in vitro in the avian testis. Differentiation 17:121–126

    Google Scholar 

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  1. Institute of Human Genetics, University of Freiburg, Albertstr. 11, D-7800, Freiburg, Federal Republic of Germany

    Ulrich Müller

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Müller, U. Identification and function of serologically detectable H-Y antigen. Hum Genet 61, 91–94 (1982). https://doi.org/10.1007/BF00274193

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  • DOI: https://doi.org/10.1007/BF00274193

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