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Inverse maternal age effect in monosomy X

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Summary

The maternal age distribution of 45,X abortuses was significantly lower than that of chromosomally normal abortuses in two co-ordinated studies. One, carried out in Geneva, included 44 X-monosomic abortuses and the other, in Hiroshima, was based on 38 abortuses with a 45,X karyotype. It was deduced that 45,X conceptuses result from either non-disjunction during paternal meiosis or anaphase lag during meiosis or mitosis, and that anaphase lag is more frequent among young couples than among older ones.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, Hiroshima, Japan

    T. Kajii & K. Ohama

  2. Department of Pediatrics, Yamaguchi University School of Medicine, 755, Ube, Yamaguchi-Ken, Japan

    T. Kajii & K. Ohama

Authors
  1. T. Kajii
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  2. K. Ohama
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Additional information

This work was supported by grants from the Ford Foundation Population Program (640-0411 B), the World Health Organization, the Swiss National Foundation and the Ministry of Culture and Education of Japan.

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Kajii, T., Ohama, K. Inverse maternal age effect in monosomy X. Hum Genet 51, 147–151 (1979). https://doi.org/10.1007/BF00287168

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  • DOI: https://doi.org/10.1007/BF00287168

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