Summary
A new variant malate dehydrogenase is described, designated S-MDHInd to indicate its discovery in the Indian subcontinent pending full comparison with all other variants. It occurred during a survey of the incidence of variant S-MDH phenotypes in 4149 subjects in north-east England and 1494 subjects from several populations in the Indian region. The variants previously thought to be restricted to the New Guinea region and to African populations occurred in three English subjects in northeast England. The incidence of variant S-MDH phenotypes in other populations is summarised.
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Beckman, G., Christodoulou, G.: Variants of soluble and mitochondrial malate dehydrogenase in the Hawaiian, Nigerian and Swedish populations. Human Heredity 24, 294–299 (1974)
Blake, N. M., Kirk, R. L., Simons, M. J., Alpers, M. P.: Genetic variants of soluble malate dehydrogenase in New Guinea population. Humangenetik 11, 72–74 (1970)
Davidson, R. G., Cortner, J. A.: Genetic variant of human erythrocyte malate dehydrogenase. Nature (Lond.) 215, 761–762 (1968a)
Davidson, R. G., Cortner, J. A.: Mitochondrial malate dehydrogenase: a new genetic polymorphism in man. Science 157, 1569–1571 (1967b)
Kirk, R. L., Blake, N. B., Lai, L. Y. C., Cooke, D. R.: Population genetic studies in Australian Aborigines of the Northern Territory. The distribution of some protein and enzyme groups among the Malag of Elcho Island. Archaeol. Phys. Anthrop. Oceania 4, 238–251 (1969)
Kirk, R. L., McDermid, E. M., Blake, N. M., Wight, R. L., Yap, E. H., Simons, J. M.: The distribution of red cell enzyme serum protein groups in a population of Dani (Pit River, West Irian). Humangenet. 17, 345 (1973)
Leakey, T. E. B., Coward, A. R., Warlow, A., Mourant, A. E.: The distribution in human populations of electrophoretic variants of cytoplasmic malate dehydrogenase. Human Heredity 22, 542–551 (1972)
Papiha, S. S., Roberts, D. F., Ali, S. G. M., Islam, M. M.: Some hereditary blood factors of the Bengali muslims of Bangladesh. Humangenetik 28, 285–293 (1975)
Papiha, S. S., Roberts, D. F.: Haptoglobin distribution in north-east England. Ann. Hum. Biol. 3, 387–390 (1976)
Roberts, D. F., Papiha, S. S., Creen, C. K., Chhaparwal, B. C., Mehta, S.: Red cell enzyme and other polymorphic systems in Madhya Pradesh, Central India. Ann. Hum. Biol. 1, 159–174 (1974)
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Papiha, S.S., Roberts, D.F. & Shah, K.C. Genetic variants of cytoplasmic malate dehydrogenase (MDH:EC:1.1.1.37) in populations in England and the Indian subcontinent. Hum Genet 36, 73–79 (1977). https://doi.org/10.1007/BF00390439
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DOI: https://doi.org/10.1007/BF00390439