Skip to main content
SpringerLink
Log in

New data on the association between PTC and thyroid diseases

  • Original Investigations
  • Published:
Humangenetik Aims and scope Submit manuscript

Summary

PTC taste thresholds were determined in 229 Caucasoid and Negroid patients with thyroid diseases and 252 controls carefully matched in relation to sex, age, race, grandparents' nationality and socioeconomic level. The majority of the affected persons had either multinodular or diffuse goiter, but individuals with uninodular goiter or hypothyroidism were also studied. Among multinodular goiter patients there is a slightly higher prevalence of non-tasters (26%) and among diffuse goiter persons a lower one (15%) as compared to controls (21%). A review of all previous studies dealing with these associations was also made; the same tendency was observed among them. The use of Woolf's method showed that these relationships were statistically significant, with no indication of heterogeneity.

Zusammenfassung

Die Schmeckfähigkeit für PTC wurde bei 229 europiden und negriden Patienten mit Schilddrüsen-Erkrankungen und bei 252 Kontrollen bestimmt, die in bezug auf die folgenden Parameter sorgfältig an die Patienten angepaßt waren: Geschlecht; Alter; Rasse; Nationalität der Großeltern; sozioökonomische Schicht. Die Mehrzahl der Patienten litt entweder an multipel-nodulärem oder an diffusem Kropf; jedoch wurden auch einzelne Personen mit einem einzigen Kropfknoten beobachtet. Unter Patienten mit multipel-nodulärem Kropf sind die Nichtschmecker etwas häufiger (26%), bei diffusem Kropf dagegen etwas seltener (15%) als bei den Kontrollen (21%). Gleichzeitig wurden die bisherigen Studien gesichtet, die sich mit diesen Assoziationen befassen. Hier wurde die gleiche Tendenz beobachtet. Mit Hilfe der Methode von Woolf konnte gezeigt werden, daß diese Assoziationen statistisch signifikant sind; es besteht kein Hinweis auf Heterogenität.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Azevêdo, E., Krieger, H., Mi, M. P., Morton, N. E.: PTC taste sensitivity and endemic goiter in Brazil. Amer. J. hum. Genet. 17, 87–90 (1965).

    PubMed  PubMed Central  Google Scholar 

  • Brand, N.: Taste sensitivity and endemic goitre in Israel. Ann. hum. Genet. 26, 321–324 (1963).

    Article  CAS  PubMed  Google Scholar 

  • Covarrubias, E., Barzelatto, J., Stevenson, C., Bobadilla, E., Pardo, A., Beckers, C.: Taste sensitivity to phenylthio-carbamide and endemic goitre among Pewenche Indians. Nature (Lond.) 205, 1036 (1965).

    Article  Google Scholar 

  • De Luca, F., Cramarossa, L.: Phenylthiourea and endemic goitre. Lancet 1965 I, 1399–1400.

    Google Scholar 

  • Fraser, G. R.: Cretinism and taste sensitivity to phenylthio-carbamide. Lancet 1961 I, 964–965.

    Google Scholar 

  • Gilson, W. E.: Achilles reflex recording with a simple photomotograph. New Engl. J. Med. 260, 1027–1028 (1959).

    Article  CAS  PubMed  Google Scholar 

  • Harris, H., Kalmus, H.: The measurement of taste sensitivity to phenylthiourea (PTC). Ann. Eugen. 15, 24–31 (1949).

    Article  CAS  PubMed  Google Scholar 

  • Harris, H., Kalmus, H., Trotter, W. R.: Taste sensitivity to phenylthiourea in goitre and diabetes. Lancet 1949 II, 1038–1039.

    Google Scholar 

  • Hollingsworth, D. R.: Phenylthiourea taste testing in Hiroshima subjects with thyroid disease. J. clin. Endocr. 23, 961–963 (1963).

    Article  CAS  PubMed  Google Scholar 

  • Kitchin, F. D., Howel-Evans, W., Clarke, C. A., McConnel, R. B., Sheppard, P. M.: P.T.C. taste response and thyroid disease. Brit. med. J. 1959 I, 1069–1074.

  • Memoria, J. M. P.: Bocio endêmico e sensibilidade à feniltiocarbamida (PTC). Anais I Reunião Brasil. Genet. Hum., Curitiba 1958, 74–76 (1959).

    Google Scholar 

  • Miluničová, A., Hájek, M.: PTC test in patients with malignant goitre (in Czech). Čas. Lék. čes. 45, 1227–1230 (1966).

    Google Scholar 

  • Roitt, I. M., Doniach, D.: Thyroid auto-immunity. Brit. med. Bull. 16, 152–158 (1960).

    CAS  PubMed  Google Scholar 

  • Shepard, T. H., II: Phenylthiocarbamide non-tasting among congenital athyrotic cretins: further studies in an attempt to explain the increased incidence. J. clin. Invest. 40, 1751–1757 (1961).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shepard, T. H., II, Gartler, S. M.: Increased incidence of nontasters of phenylthiocarbamide among congenital athyreotic cretins. Science 131, 929 (1960).

    Article  PubMed  Google Scholar 

  • Taunton, O. D., McDaniel, H. G., Pittman, J. A., Jr.: Standardization of TSH testing. J. clin. Endocr. 25, 266–277 (1965).

    Article  CAS  PubMed  Google Scholar 

  • Vogel, F.: AB0 blood groups and disease. Amer. J. hum. Genet. 22, 464–475 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  • Werner, S. C., Spooner, M.: A new and simple test for hyperthyroidism employing 1-triiodothyronine and the twenty-four-hour 131I uptake method. Bull. N. Y. Acad. Med. 31, 137–145 (1955).

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wiener, A. S.: Blood groups and disease. Amer. J. hum. Genet. 22, 476–483 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  • Woolf, B.: On estimating the relation between blood group and disease. Ann. hum. Genet. 19, 251–253 (1955).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Pôrto Alegre, Brazil

    Heirie M. Mendez de Araújo, F. M. Salzano & Henry Wolff

  2. Disciplina de Endocrinologia e Nutrologia, Faculdade Católica de Medicina, Pôrto Alegre, Brazil

    Heirie M. Mendez de Araújo, F. M. Salzano & Henry Wolff

Authors
  1. Heirie M. Mendez de Araújo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. M. Salzano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Henry Wolff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mendez de Araújo, H.M., Salzano, F.M. & Wolff, H. New data on the association between PTC and thyroid diseases. Hum Genet 15, 136–144 (1972). https://doi.org/10.1007/BF00295740

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00295740

Keywords

Search

Navigation