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Cytoplasmic inheritance of erythromycin resistant mutations in Paramecium aurlia

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Summary

Erythromycin inhibits the growth of wild type Paramecia and eventually kills the cells. 24 erythromycin resistant mutants (22 U.V. induced, 2 spontaneous) have been isolated. They fall into att least three phenotypic classes on the basis of their level of resistance and of thermosensitivity.

Genetic analysis of three mutants shows that the resistance character is cytoplasmically inherited, as evidenced by its clonal inheritance, its transfer through cytoplasmic bridges and its non-segregation at meiosis.

The results suggest that these mutants may be mitochondrial mutants analogous to those described in yeast.

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Authors and Affiliations

  1. Laboratoire de Génétique, Faculté des Sciences, 91, Orsay, France

    Andre Adoutte & Janine Beisson

  2. Laboratoire associé no 86 du Centre National de la Recherche Scientifique, France

    Andre Adoutte & Janine Beisson

Authors
  1. Andre Adoutte
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  2. Janine Beisson
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Communicated by P. Slonimski

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Adoutte, A., Beisson, J. Cytoplasmic inheritance of erythromycin resistant mutations in Paramecium aurlia . Molec. Gen. Genetics 108, 70–77 (1970). https://doi.org/10.1007/BF00343186

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  • DOI: https://doi.org/10.1007/BF00343186

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