Summary
Comparative investigations concerning the action of streptomycin (SM) and dihydrostreptomycin (DHSM) on human chromosomes in vitro revealed a strong effectivity of SM in inducing achromatic lesions (AL) while DHSM is ineffective in this respect. Chromatid breaks (B′) and isochromatid breaks (B″) are not induced by the two streptomycins. Chromatid translocations (RB') were found only 3 times in all concentrations tested. The intrachromosomal distribution of the streptomycin-induced AL is very similar to the distribution of AL induced with the alkylating agent Chinon I and the thioxanthon derivative Miracil D. The view is discussed that the appearance of achromatic lesions cannot be interpreted as an indicator for a mutagenic activity of an agent.
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Vorgelegt von Ch. Auerbach
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Obe, G. Die Wirkung von Streptomycin und Dihydrostreptomycin auf menschliche Chromosomen in vitro . Molec. Gen. Genet. 107, 361–365 (1970). https://doi.org/10.1007/BF00441197
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DOI: https://doi.org/10.1007/BF00441197