Abstract
To investigate the mechanism by which liver weight increases during plerocercoid infections as well as the possible existence of a hepatocyte-growth-factor (HGF)-like substance in the serum of mice infected withSpirometra erinacei plerocercoids, liver DNA synthesis was measured in vivo and in vitro. Infection withS. erinacei plerocercoids significantly stimulated DNA synthesis in mouse parenchymal hepatocytes prior to the increase in liver weight, at least partly by stimulating the induction of the salvage pathways of pyrimidine biosynthesis. Furthermore, infected mouse serum directly stimulated DNA synthesis in cultured mouse parenchymal hepatocytes. These results suggest that an HGF-like substance is present in the serum of mice infected withS. erinacei plerocercoids.
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Tsuboi, T., Torii, M., Oka, K. et al. Hepatotrophic activity in mouse serum infected with plerocercoids ofSpirometra erinacei . Parasitol Res 80, 629–633 (1994). https://doi.org/10.1007/BF00932943
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DOI: https://doi.org/10.1007/BF00932943