Summary
Thymocyte subpopulations that are associated with macrophages and dendritic cells of the thymus in vivo were isolated from the thymuses of C57Bl/6 mice, and their Lyt phenotypes were analyzed. Electron-microscopic examination of immunogold-labeled cells revealed that the thymic complexes formed by macrophages mainly contained Lyt-2-positive thymocytes, while Lyt-1-positive thymocytes were more frequently associated with dendritic cells. The characteristic distributions of Lyt antigens on the surface of thymocytes in regions of reciprocal contact with macrophages (Lyt-2-positive cells) and dendritic cells (Lyt-1-positive cells) suggest that these antigens play a role in specific interactions between thymocytes and stroma cells.
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Dedicated to Professor Dr. T.H. Schiebler on the occasion of his 65th birthday
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Brelińska, R., Warchol, J.B., Boniver, J. et al. Distribution of Lyt antigens on the surface of thymocytes associated with thymic macrophages and dendritic cells. Histochemistry 88, 553–556 (1988). https://doi.org/10.1007/BF00570323
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DOI: https://doi.org/10.1007/BF00570323