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Immunohistochemical demonstration of serotonin nerve fibers in the olfactory bulb of the rat, cat and monkey

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Summary

The distribution of serotonin (5-HT) positive fibers in the olfactory bulb of the rat, cat and monkey was studied using the peroxidase-anti-peroxidase (PAP) immunohistochemical method and highly specific antibodies to 5-HT. In general, 5-HT fibers were present throughout all layers in the olfactory bulb of these species except for the olfactory nerve layer and different as well as restricted laminar patterns of 5-HT distribution were observed. There were also species-related differences in the pattern of 5-HT distribution, in each layer. The most notable species difference was apparent in the glomerular layer of the main olfactory bulb. In case of the rat and cat, a very dense plexus of 5-HT fibers was observed to be diffuse in the glomerulus, while in the monkey, the distribution of 5-HT fibers was scanty and partial, as was seen in the accessory olfactory bulb of the rat.

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Authors and Affiliations

  1. Department of Anatomy, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji Kamikyo-Ku, 602, Kyoto, Japan

    Y. Takeuchi & Y. Sano

  2. Department of Anatomy, Shiga University of Medical Science Otsu, Shiga, Japan

    H. Kimura

Authors
  1. Y. Takeuchi
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  2. H. Kimura
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  3. Y. Sano
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Additional information

This work was supported by grant (No. 56440022) from the Ministry of Education, Science and Culture, Japan

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Takeuchi, Y., Kimura, H. & Sano, Y. Immunohistochemical demonstration of serotonin nerve fibers in the olfactory bulb of the rat, cat and monkey. Histochemistry 75, 461–471 (1982). https://doi.org/10.1007/BF00640598

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  • DOI: https://doi.org/10.1007/BF00640598

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