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Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon

I. Effects of nitrogen sources on the production of shikonin derivatives

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Abstract

Shikonin derivatives were produced from cell suspension cultures of Lithospermum erythrorhizon for the first time. The results of studies on various culture media showed that the type of nitrogen source in the medium greatly influenced the production of these derivatives. When nitrate was the nitrogen source, stable production of shikonin derivatives by the cell suspension culture took place. We also found that ammonium as the nitrogen source conspicuously inhibited the production of shikonin derivatives.

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Authors and Affiliations

  1. Research Center, Mitsui Petrochemical Industries, Ltd., 6-1-2, Waki-cho, Kuga-gun, 740, Yamaguchi-ken, Japan

    Yasuhiro Fujita, Yasuhiro Hara, Takao Ogino & Chuzo Suga

Authors
  1. Yasuhiro Fujita
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  2. Yasuhiro Hara
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  3. Takao Ogino
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  4. Chuzo Suga
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Fujita, Y., Hara, Y., Ogino, T. et al. Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon . Plant Cell Reports 1, 59–60 (1981). https://doi.org/10.1007/BF00269272

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  • DOI: https://doi.org/10.1007/BF00269272

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