Summary
Glucose, 2-deoxy glucose and inorganic phosphate inhibited tylosin production and fatty acid oxidation in Streptomyces T 59–235. Glucose-6-phosphate was accumulated in high-phosphate cultures. The possible function of glucose phosphate as a common mediator of both glucose and phosphate effects is discussed.
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References
Chen PS, Toribara TY, Warner H (1956) Anal Chem 28: 1756–1758
David HL (1977) J Gen Microbiol 101: 99–102
Demain AL, Inamine E (1970) Bacteriol Rev 34: 1–19
Dietz GW, Heppel LA (1971) J Biol Chem 246: 2881–2884
Drew SW, Demain AL (1977) Ann Rev Microbiol 31: 343–356
Kimmich GA, Randles J, Brand JS (1975) Anal Biochem 69: 187–206
Lamprecht W, Trautschold I (1970) In: Bergmeyer HU (ed): Methoden der enzymatischen Analyse, Vol 2. Verlag Chemie, Weinheim, pp 2024–2033
Liras P, Villanueva JP, Martin JF (1977) J Gen Microbiol 102: 269–277
Martin JF (1976) Microbiology 1976. American Society for Microbiology, Washington, DC, pp 548–552
Martin JF (1977) Advanced biochemistry engineering. In: Ghose TK, Fiechter A, Blakebrough N (eds) Vol. 6. Springer; Berlin Heidelberg New York, pp 105–127
Sprinkmeyer R, Pape H (1978) In: Freerksen E, Tarnok I, Thumim JH (eds) Genetics of the actinomycetales. Gustav Fischer, Stuttgart New York, pp 51–58
Walker MS, Walker JB (1971) J Biol Chem 246: 7034–7040
Weber MJ (1973) J Biol Chem 248: 2978–2983
Weinberg ED (1974) Dev Ind Microbiol 15: 70–81
Witney FR, Failla ML, Weinberg ED (1977) Appl Environ Microbiol 33: 1042–1046
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Madry, N., Sprinkmeyer, R. & Pape, H. Regulation of tylosin synthesis in Streptomyces: Effects of glucose analogs and inorganic phosphate. European J. Appl. Microbiol. Biotechnol. 7, 365–370 (1979). https://doi.org/10.1007/BF00499851
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DOI: https://doi.org/10.1007/BF00499851