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Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen→q13

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Abstract

A cDNA clone has recently been isolated that encodes a protein expressed only in the intermediate and late stages of T-cell differentiation, termed MAL. The polypeptide deduced from the MAL cDNA sequence contains four potential transmembrane domains. We have used a panel of 28 human × rodent hybrid cell lines to assign the MAL gene to the proximal long arm of human chromosome 2, region cen→q13. The significance of the MAL map position and its relationship with other genes on chromosome 2 are discussed.

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Author notes

  1. Miguel A. Alonso

    Present address: Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Canto Blanco, Madrid, Spain

Authors and Affiliations

  1. Department of Human Genetics, Yale University School of Medicine, 06510, New Haven, CT, USA

    Miguel A. Alonso, David E. Barton & Uta Francke

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  1. Miguel A. Alonso
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  2. David E. Barton
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  3. Uta Francke
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Alonso, M.A., Barton, D.E. & Francke, U. Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen→q13 . Immunogenetics 27, 91–95 (1988). https://doi.org/10.1007/BF00351081

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  • DOI: https://doi.org/10.1007/BF00351081

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